Living related and living unrelated kidney transplantations: A systematic review and meta-analysis

World Journal of Transplantation
Nasser SimforooshMehdi Sotoudeh

Abstract

To compare the outcomes between related and unrelated kidney transplantations. Literature searches were performed following the Cochrane guidelines. We conducted a systematic review and a meta-analysis, which included 12 trials that investigated outcomes including the long-term (ten years), mid-term (one to five years), and short-term (one year) graft survival rate as well as the acute rejection rate. Meta-analyses were performed using fixed and random-effects models, which included tests for publication bias and heterogeneity. No difference in graft survival rate was detected in patients who underwent living related kidney transplantations compared to unrelated (P = 0.44) transplantations after ten years. There were no significant differences between the graft survival rate in living related and unrelated kidney transplantations after a short- and mid-term follow-up (P = 0.35, P = 0.46). There were no significant differences between the acute rejection rate in living related and unrelated kidney transplantations (P = 0.06). The long, mid and short term follow-up of living related and unrelated kidney transplantation showed no significant difference in graft survival rate. Also, acute rejection rate was not significantly differ...Continue Reading

Citations

Oct 7, 2020·Transplant International : Official Journal of the European Society for Organ Transplantation·Samar Abd ElHafeezKitty J Jager
Dec 1, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Piotr WitkowskiUNKNOWN “Islets for US” Collaborative

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