Living related kidney donation as an advantage for growth of children independent of glomerular filtration rate

Transplantation Proceedings
Lars PapeG Offner

Abstract

Seventy-two pediatric kidney recipients of living related donors (LRD) and 145 of cadaveric donors (CAD) were analyzed for height standard deviation scores (Ht-SDS) and glomerular filtration rates (GFR) directly after transplantation and over the following 5 years. GFR was significantly higher immediately after transplantation in LRD compared with CAD recipients; however, GFR was not different during the 5-year follow-up period. Although Ht-SDS was comparable at the time of transplantation in both groups, it was significantly higher among LRD recipients over the next 5 years. Multivariate and covariate analyses showed that Ht-SDS after 5 years was mainly influenced only by CAD vs LRD and not by GFR or other factors, namely, donor age, rejections, time of dialysis, preemptive transplantation, age at transplantation, or immunosuppression. Thus, children receiving grafts from LRD showed a better catch-up growth independent of the GFR than those after CAD transplantation. We concluded that the period of donor death and prolonged cold ischemia in CAD grafts may lead to changes in gene expression of cytokines and other mediator molecules that affect bone metabolism. Better growth seems to be an additional factor supporting the policy...Continue Reading

References

Sep 17, 1998·The Journal of Pediatrics·H MaxwellL Rees
Dec 17, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Abhay VatsBlanche Chavers
Jul 16, 2004·Kidney International·Richard NisselDieter Haffner

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Citations

May 28, 2013·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Doris FrankeMiroslav Zivičnjak
Apr 5, 2008·Acta Clinica Belgica·R Van Damme-Lombaerts
Mar 11, 2011·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Hongying TangAlexander S Goldfarb-Rumyantzev

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