PMID: 16514175Mar 4, 2006Paper

Lixazinone stimulates mitogenesis of Madin-Darby canine kidney cells

Experimental Biology and Medicine
Jingfei ChengJ P Grande

Abstract

Polycystic kidney diseases (PKD) are characterized by excessive proliferation of renal tubular epithelial cells, development of fluid-filled cysts, and progressive renal insufficiency. cAMP inhibits proliferation of normal renal tubular epithelial cells but stimulates proliferation of renal tubular epithelial cells derived from patients with PKD. Madin-Darby canine kidney (MDCK) epithelial cells, which are widely used as an in vitro model of cystogenesis, also proliferate in response to cAMP. Intracellular cAMP levels are tightly regulated by phosphodiesterases (PDE). Isoform-specific PDE inhibitors have been developed as therapeutic agents to regulate signaling pathways directed by cAMP. In other renal cell types, we have previously demonstrated that cAMP is hydrolyzed by PDE3 and PDE4, but only PDE3 inhibitors suppress proliferation by inhibiting Raf-1 activity (Cheng J, Thompson MA, Walker HJ, Gray CE, Diaz Encarnacion MM, Warner GM, Grande JP. Am J Physiol Renal Physiol 287:F940-F953, 2004.) A potential role for PDE isoform(s) in cAMP-mediated proliferation of MDCK cells has not previously been established. Similar to what we have previously found in several other renal cell types, cAMP hydrolysis in MDCK cells is directed ...Continue Reading

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Citations

Dec 7, 2013·Endocrine Reviews·Monalisa F AzevedoConstantine A Stratakis
Apr 15, 2015·Nature Reviews. Nephrology·Fouad T ChebibVicente E Torres
Jul 28, 2017·PloS One·Xiaofang WangVicente E Torres
Sep 17, 2015·Journal of the American Society of Nephrology : JASN·Hong YeVicente E Torres
Dec 18, 2013·Journal of the American Society of Nephrology : JASN·Vicente E Torres, Peter C Harris
Apr 27, 2020·Cellular Signalling·Caroline R SussmanVicente E Torres
Jun 24, 2009·European Journal of Pharmacology·Balam MuñozEsther López-Bayghen
Nov 20, 2009·Kidney International·Xiaofang WangVicente E Torres

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