Abstract
Type 2 diabetes (T2D) is a highly prevalent disorder that affects millions of people worldwide. The hallmark of T2D is hyperglycemia and, while many treatment modalities exist, achieving and maintaining glycemic control can be challenging. Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are an appealing treatment option as they improve glycemic control, reduce weight, and limit the risk of hypoglycemia. Lixisenatide is a once-daily GLP-1 RA that has been evaluated in the GetGoal clinical trial program and has demonstrated efficacy and tolerability across a spectrum of patients. The feature that most distinguishes lixisenatide from other GLP-1 RAs is its ability to substantially reduce postprandial glucose (PPG) for the meal immediately following injection. Because of its positive effects on PPG, lixisenatide is being considered as a replacement for prandial insulin, and a fixed dose combination product containing lixisenatide and basal insulin is in development. Lixisenatide is a promising new addition to the antidiabetic armamentarium, but due to the lack of real-world experience with the drug, its exact place in therapy is unknown.
References
Apr 28, 2004·Diabetes Care·Sarah WildHilary King
Mar 21, 2008·Trends in Molecular Medicine·Jens J HolstSten Madsbad
Apr 8, 2010·The Annals of Pharmacotherapy·Sarah L Anderson, Jennifer M Trujillo
Jun 24, 2010·Regulatory Peptides·Ulrich WernerWerner Kramer
Aug 21, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·R E RatnerUNKNOWN DRI6012 Study Investigators
Oct 29, 2010·Diabetes·Simin Liu, Yiqing Song
Mar 21, 2012·Diabetes Care·Vivian A FonsecaUNKNOWN EFC6018 GetGoal-Mono Study Investigators
Apr 21, 2012·Diabetes Care·Silvio E InzucchiUNKNOWN European Association for the Study of Diabetes (EASD)
May 9, 2012·Diabetes, Obesity & Metabolism·Y SeinoUNKNOWN EFC10887 GETGOAL-L Asia Study Investigators
Feb 2, 2013·Diabetes, Obesity & Metabolism·C KapitzaA Hincelin-Méry
Mar 29, 2013·Diabetes Care·Bo AhrénRonnie Aronson
Apr 9, 2013·Diabetes Care·Matthew C RiddleJulio Rosenstock
May 1, 2013·Diabetes, Obesity & Metabolism·M PingetR Aronson
May 1, 2013·Diabetes Care·Matthew C RiddleJulio Rosenstock
May 24, 2013·Diabetes Care·Julio RosenstockJohn E Gerich
Jul 5, 2013·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Andreas B Petersen, Mikkel Christensen
Oct 15, 2013·Diabetic Medicine : a Journal of the British Diabetic Association·G B BolliM Hanefeld
Feb 15, 2014·Diabetes, Obesity & Metabolism·Y SeinoUNKNOWN PDY6797 investigators
Mar 19, 2014·Diabetes/metabolism Research and Reviews·Chang Yu PanElisabeth Niemoeller
Mar 22, 2014·Journal of Diabetes and Its Complications·Julio RosenstockRobert E Ratner
Aug 20, 2012·Journal of Diabetes Investigation·Daisuke Yabe, Yutaka Seino
May 31, 2014·Journal of Diabetes Science and Technology·Udo StauderSteve Edelman
Aug 15, 2014·Diabetes/metabolism Research and Reviews·Denis RaccahJohn Gerich
Dec 30, 2014·Diabetes Care·UNKNOWN American Diabetes Association
Apr 19, 2015·Diabetes Care·Juris J MeierChristoph Kapitza
Citations
Aug 27, 2016·Expert Opinion on Investigational Drugs·Brian TomlinsonZhong-Min Liu
Nov 4, 2016·Expert Opinion on Drug Metabolism & Toxicology·Markolf HanefeldLouis Monnier
Mar 10, 2018·Postgraduate Medicine·Ian BlumerTricia Santos Cavaiola
Oct 27, 2018·Current Medical Research and Opinion·Juan Pablo FriasNeil Skolnik
Jul 26, 2017·Current Medical Research and Opinion·Neil SkolnikEric L Johnson
Aug 25, 2017·Current Medical Research and Opinion·Ronald M Goldenberg, Lori Berard
Jul 31, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Sanjay KalraManilka Sumanatilleke
Jun 28, 2018·Hormones : International Journal of Endocrinology and Metabolism·Dimitrios SfairopoulosEvangelos Liberopoulos
Jul 2, 2017·Drugs·Lesley J Scott
May 8, 2018·Nature Reviews. Endocrinology·Andreas AndersenTina Vilsbøll
Jun 22, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Markolf HanefeldJochen Seufert
Dec 8, 2016·Expert Opinion on Drug Safety·Denis Raccah
Oct 9, 2019·MSystems·Han ZhaoQi Liu
Feb 5, 2021·International Journal of Pharmaceutics·Noura G EissaAyat Allam
Feb 6, 2020·Bioorganic & Medicinal Chemistry·Jayanta Dowarah, Ved Prakash Singh
Jul 4, 2020·Biochemical Pharmacology·Helen C MendelMarkus Muttenthaler