PMID: 15230288Jul 3, 2004Paper

LJP 1082: a toleragen for Hughes syndrome

Lupus
Joan T Merrill

Abstract

A hallmark of systemic lupus erythematosus (SLE) and related autoimmune diseases such as the antiphospholipid syndrome (APL or Hughes syndrome) is an apparent breakdown in tolerance, the process by which the body distinguishes self from nonself in order to maintain a versatile immune defense while protecting itself from self-annihilation. To some extent, loss of tolerance is a desirable feature of host immunity, and is known to occur in healthy individuals. Optimal tolerance then is probably not an all or nothing phenomenon. Autoimmunity should be seen as a breakdown in homeostasis rather than a completely aberrant kind of immunity. This leads to special considerations in the assessment of potentially toleragenic therapies, in which an attempt is made to re-educate the immune system. LJP 1082 is designed as a polyvalent antigenic structure aimed at crosslinking specific surface immunoglobulin and tolerizing B cells to beta2-glycoprotein I. Issues of antigenic selection and multiplex forces influencing tolerance and immunity may have impact on its optimal development and use in patients.

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·G J Nossal, M Karvelas
Aug 22, 1986·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·G J Nossal
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·G J NossalB Pulendran
Apr 1, 1996·The Journal of Laboratory and Clinical Medicine·Z J Pan, H A Stafford
Apr 1, 1996·Lupus·S M CouttsC M Berner
Jan 20, 1998·Arthritis and Rheumatism·C J AndersonH A Stafford
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·G M IversonD M Marquis
Feb 18, 1999·Journal of Immunological Methods·J A LebrónS Ou
Jul 27, 2000·Seminars in Immunology·R M Zinkernagel
Dec 16, 2000·Expert Opinion on Investigational Drugs·D J Wallace
Sep 19, 2001·The Journal of Experimental Medicine·S MirshahidiS Sadegh-Nasseri
Oct 12, 2001·Immunologic Research·H A DoyleM J Mamula
Oct 11, 2002·Advances in Cancer Research·Thierry DefrancePeter H Krammer
Dec 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·G Michael IversonMatthew D Linnik
Mar 5, 2003·Annual Review of Immunology·Ralph M SteinmanMichel C Nussenzweig
Apr 3, 2003·Biochemical and Biophysical Research Communications·Andries ZijlstraJames P Quigley
May 3, 2003·Annals of the New York Academy of Sciences·Sun Jung KimKeith B Elkon
May 3, 2003·Annals of the New York Academy of Sciences·Kenneth M KaufmanJudith A James
Jul 15, 2003·Immunologic Research·Andrew J Caton
Sep 10, 2003·Current Opinion in Rheumatology·Virginia PascualA Karolina Palucka
Oct 17, 2003·Current Drug Targets. Inflammation and Allergy·Hitoshi Ohmori, Naoki Kanayama
Oct 17, 2003·The New England Journal of Medicine·Melissa R ArbuckleJohn B Harley
Nov 25, 2003·Current Opinion in Immunology·Michael T SpiottoHans Schreiber

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Citations

Dec 2, 2004·Nature Reviews. Drug Discovery·Joan T MerrillJill P Buyon
Jul 12, 2005·Southern Medical Journal·Lisa R Sammaritano
Nov 6, 2004·Current Rheumatology Reports·Christopher Wu, Kenneth Kalunian
Mar 11, 2005·Expert Opinion on Emerging Drugs·Joan T Merrill
Jul 16, 2008·La Revue de médecine interne·Z AmouraJ-C Piette
Mar 30, 2007·Journal of Autoimmunity·Miri Blank, Yehuda Shoenfeld
Mar 1, 2006·Rheumatic Diseases Clinics of North America·Doruk Erkan, Michael D Lockshin
Apr 6, 2005·Lupus·S Vasoo, G R V Hughes
Dec 19, 2006·Plant Biotechnology Journal·Jim M Dunwell

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