LMCT transition-based red-light photochemotherapy using a tumour-selective ferrocenyl iron(iii) coumarin conjugate.

Chemical Communications : Chem Comm
Tukki SarkarAkhtar Hussain

Abstract

A rationally designed iron(iii) complex (2a) with pendant ferrocene and naturally occurring coumarin (esculetin) shows LMCT transition-based mitochondria-targeted red-light (600-720 nm) induced apoptotic toxicity against cancer cells but remains innocuous in the dark and to normal cells.

References

Sep 1, 1986·Contact Dermatitis·B M Hausen, M Schmieder
Jul 6, 2000·Journal of Photochemistry and Photobiology. B, Biology·E DelaeyP de Witte
Mar 22, 2001·Advanced Drug Delivery Reviews·D Hörter, J B Dressman
Aug 19, 2007·Chemical Communications : Chem Comm·Lu ZhangLei Zhu
Aug 29, 2007·Inorganic Chemistry·Pieter C A BruijnincxRobertus J M Klein Gebbink
Dec 4, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Karuppasamy SundaravelMallayan Palaniandavar
Jan 27, 2009·Chemical Society Reviews·Christian G Hartinger, Paul J Dyson
May 15, 2010·Nature Reviews. Drug Discovery·Simone FuldaGuido Kroemer
Feb 1, 2012·Angewandte Chemie·Uttara BasuAkhil R Chakravarty
Mar 1, 2012·Current Opinion in Chemical Biology·Gilles Gasser, Nils Metzler-Nolte
Oct 12, 2012·Angewandte Chemie·Samantha L H Higgins, Karen J Brewer
Aug 29, 2013·Dalton Transactions : an International Journal of Inorganic Chemistry·Anna LeonidovaGilles Gasser
Mar 8, 2016·Dalton Transactions : an International Journal of Inorganic Chemistry·Tukki SarkarAkhtar Hussain
Jul 19, 2018·Chembiochem : a European Journal of Chemical Biology·Huaiyi HuangPeter J Sadler
May 8, 2019·Photodiagnosis and Photodynamic Therapy·Behzad MansooriMichael R Hamblin
Sep 25, 2019·Nature Chemistry·Huaiyi HuangPeter J Sadler
Dec 17, 2019·ChemMedChem·Anna NotaroAnnie Castonguay

❮ Previous
Next ❯

Citations

Aug 11, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Mathilde BouchéPhilippe C Gros
Jan 23, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aitor CarneiroLourdes Santana
Jun 20, 2021·Advanced Science·Jiating XuYujie Fu

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
confocal microscopy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Pharmacology and Experimental Therapeutics
L W HAZLETONB R ZEITLIN
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
© 2022 Meta ULC. All rights reserved