LMO1 super-enhancer polymorphism rs2168101 G>T correlates with decreased neuroblastoma risk in Chinese children

Journal of Cancer
Jing HeYan Zou

Abstract

Neuroblastoma is one of the most frequently occurring childhood cancers. The rs2168101 G>T polymorphism observed in the LMO1 gene is located at a conserved GATA transcription factor binding motif. This polymorphism was reported to be significantly associated with neuroblastoma susceptibility. However, whether this and other functional polymorphisms can affect neuroblastoma risk of Chinese children remains unknown. We conducted a two-center hospital-based case-control study with a total of 374 cases and 812 controls to assess the role of five LMO1 gene polymorphisms in the neuroblastoma risk. We confirmed that rs2168101 G>T was significantly associated with decreased neuroblastoma risk for both northern and southern Chinese children and the combined subjects [GT vs. GG: adjusted odds ratio (OR)=0.57, 95% confidence interval (CI)=0.44-0.74, P<0.0001; TT vs. GG: adjusted OR=0.29, 95% CI=0.15-0.56, P=0.0002; GT/TT vs. GG: adjusted OR=0.53, 95% CI=0.41-0.68, P<0.0001; and TT vs. GT/GG: adjusted OR=0.36, 95% CI=0.19-0.69, P=0.002] after adjustment for age and gender. This association was further confirmed by performing a stratifying analysis and a false-positive report probability analysis. Similar results were observed for the rs375...Continue Reading

Citations

May 5, 2020·Journal of Clinical Laboratory Analysis·Fei MaoHeng-Bing Wang
May 21, 2019·Frontiers in Pharmacology·Yi HeQing Liu
May 23, 2020·Pharmacogenomics and Personalized Medicine·Yi ZhengWei Zhong
Aug 28, 2020·Pharmacogenomics and Personalized Medicine·Yun ZhuWei Zhong
Oct 27, 2020·The Journal of International Medical Research·Yi ZhengWei Zhong

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Methods Mentioned

BETA
RNA-seq
acetylation

Software Mentioned

SNPinfo

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