LMP-1 induces survivin expression to inhibit cell apoptosis through the NF-κB and PI3K/Akt signaling pathways in nasal NK/T-cell lymphoma

Oncology Reports
Lu SunLixin Wei

Abstract

The latent membrane protein-1 (LMP-1) is essential for Epstein-Barr virus (EBV)-induced nasal natural killer/T-cell lymphoma (NKTL). The aim of the present study was to evaluate the role of LMP-1 in NKTL. Two human EBV-positive NKTL cell lines (SNK-6 and SNT-8) were transfected with pcDNA3.1-LMP-1 or LMP-1 siRNA. Compared with the blank control, the cell apoptosis rates were decreased by 10.31 and 12.05% after pcDNA3.1-LMP-1 transfection and increased by 41.48 and 35.63% after lentiviral LMP-1 siRNA infection in the SNK-6 and SNT-8 cells. Survivin expression was induced by LMP-1, and the effect was attenuated by inhibitors of survivin, NF-κB and PI3K/Akt. Reduction in cell apoptosis by LMP-1 was also inhibited by inhibitors of survivin, NF-κB and PI3K/Akt. For the in vivo assay, tumor-bearing mice were established by subcutaneous injection with differentially treated SNT-8 cells into the back of the nude mice, and the tumor growth in the different groups was recorded. The results revealed that tumor formation and growth were also inhibited by treatment with survivin, NF-κB and PI3K/Akt inhibitors. Collectively, LMP-1-induced survivin expression inhibited cell apoptosis through the NF-κB and PI3K/Akt pathways, and survivin may b...Continue Reading

References

Jan 1, 1989·Cancer Chemotherapy and Pharmacology·M M Tomayko, C P Reynolds
Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Oct 26, 2005·Oncogene·N J ThornburgN Raab-Traub
Feb 8, 2008·International Journal of Hematology·Katsuyuki AozasaWoo-Ick Yang
Sep 2, 2010·World Journal of Gastroenterology : WJG·Mihaela Petrova, Victor Kamburov
Dec 15, 2010·International Journal of Biological Sciences·Zhi-Ming Zheng
Nov 10, 2013·OncoTargets and Therapy·Chun Hei Antonio CheungJang-Yang Chang

❮ Previous
Next ❯

Citations

Jul 18, 2015·International Journal of Surgical Pathology·Jian-Chen FangZheng Li
Oct 13, 2017·Head & Neck·Anthony A FirekSalma Khan
Jan 22, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Toshihiro NagatoYasuaki Harabuchi
Feb 2, 2018·Journal of Experimental & Clinical Cancer Research : CR·Shao Jie WuKun Yuan Guo
Jan 13, 2017·Oncotarget·Jayaraju DheekolluPaul M Lieberman
May 30, 2019·Frontiers in Oncology·Qingqing CaiKen H Young
Jul 3, 2019·Frontiers in Oncology·Mei Mei, Mingzhi Zhang
Mar 5, 2020·Therapeutic Advances in Medical Oncology·Can KüçükHua You
Oct 4, 2015·Current Hematologic Malignancy Reports·Mamiko Sakata-Yanagimoto, Shigeru Chiba
Jul 26, 2016·Experimental and Therapeutic Medicine·Hua YangYuren Xi
Oct 20, 2020·Infectious Agents and Cancer·J CharostadE Faghihloo
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·YingYu ZhangJunQi Niu
Oct 17, 2020·Cancer Management and Research·Mei ZengYan Liu
Apr 4, 2021·Cancers·Ivonne A Montes-MojarroLeticia Quintanilla-Martinez
Mar 17, 2019·Experimental and Molecular Pathology·Mario Alejandro LorenzettiMaría Victoria Preciado

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis