Abstract
The latent membrane protein-1 (LMP-1) is essential for Epstein-Barr virus (EBV)-induced nasal natural killer/T-cell lymphoma (NKTL). The aim of the present study was to evaluate the role of LMP-1 in NKTL. Two human EBV-positive NKTL cell lines (SNK-6 and SNT-8) were transfected with pcDNA3.1-LMP-1 or LMP-1 siRNA. Compared with the blank control, the cell apoptosis rates were decreased by 10.31 and 12.05% after pcDNA3.1-LMP-1 transfection and increased by 41.48 and 35.63% after lentiviral LMP-1 siRNA infection in the SNK-6 and SNT-8 cells. Survivin expression was induced by LMP-1, and the effect was attenuated by inhibitors of survivin, NF-κB and PI3K/Akt. Reduction in cell apoptosis by LMP-1 was also inhibited by inhibitors of survivin, NF-κB and PI3K/Akt. For the in vivo assay, tumor-bearing mice were established by subcutaneous injection with differentially treated SNT-8 cells into the back of the nude mice, and the tumor growth in the different groups was recorded. The results revealed that tumor formation and growth were also inhibited by treatment with survivin, NF-κB and PI3K/Akt inhibitors. Collectively, LMP-1-induced survivin expression inhibited cell apoptosis through the NF-κB and PI3K/Akt pathways, and survivin may b...Continue Reading
References
Jan 1, 1989·Cancer Chemotherapy and Pharmacology·M M Tomayko, C P Reynolds
May 15, 1996·Cancer·Y HarabuchiS Kon
Mar 1, 1996·The Journal of Pathology·P KanavarosP Gaulard
Aug 1, 1997·Nature Medicine·G AmbrosiniD C Altieri
Feb 4, 1998·Virology·M L Roberts, N R Cooper
Sep 12, 1998·Journal of Virology·O DevergneE Kieff
Apr 15, 2000·Gut·A I SarelaP J Guillou
Feb 7, 2001·Blood·H NagataN Shimizu
Mar 14, 2003·Journal of Virology·Honglin ChenS Diane Hayward
Oct 26, 2005·Cell Research·Mi Dan AiYa Cao
Oct 26, 2005·Oncogene·N J ThornburgN Raab-Traub
Jan 31, 2008·Blood·Ilaria GuasparriEthel Cesarman
Feb 8, 2008·International Journal of Hematology·Katsuyuki AozasaWoo-Ick Yang
Mar 5, 2008·Cancer Research·Rumi HinoMasashi Fukayama
Mar 28, 2008·Journal of Virology·Che-Pei Kung, Nancy Raab-Traub
Dec 3, 2008·Pathology Oncology Research : POR·Safiye AktaşCanan Vergin
Mar 3, 2009·Cancer Letters·Jeng-Woei LeeWen-Ling Shih
Aug 6, 2010·Journal of Virology·Sophia SpadavecchiaDavid M Lukac
Sep 2, 2010·World Journal of Gastroenterology : WJG·Mihaela Petrova, Victor Kamburov
Dec 15, 2010·International Journal of Biological Sciences·Zhi-Ming Zheng
Feb 5, 2011·The Journal of Pathology·Siok-Bian NgWee-Joo Chng
Dec 12, 2012·The Journal of General Virology·Kazuhira EndoJoseph S Pagano
Aug 22, 2013·American Journal of Hematology·Yuki KomabayashiYasuaki Harabuchi
Nov 10, 2013·OncoTargets and Therapy·Chun Hei Antonio CheungJang-Yang Chang
Jan 7, 2014·Molecular Cancer·Da-Liang OuAnn-Lii Cheng
Mar 13, 2014·FEBS Letters·Lei MaJianqing Huang
Apr 18, 2014·Stem Cell Research & Therapy·Ihn HanSung-Hoon Kim
May 13, 2014·The FEBS Journal·Yi ZhaoXin-Rong Hu
Citations
Jul 18, 2015·International Journal of Surgical Pathology·Jian-Chen FangZheng Li
Oct 13, 2017·Head & Neck·Anthony A FirekSalma Khan
Mar 6, 2018·European Journal of Haematology·Lei-Lei ZhouJi-Feng Feng
Jan 22, 2019·Laboratory Investigation; a Journal of Technical Methods and Pathology·Toshihiro NagatoYasuaki Harabuchi
Feb 2, 2018·Journal of Experimental & Clinical Cancer Research : CR·Shao Jie WuKun Yuan Guo
Jan 13, 2017·Oncotarget·Jayaraju DheekolluPaul M Lieberman
Dec 24, 2016·Oncotarget·Yuan MaoJin Zhu
Jan 2, 2018·Oncotarget·Chen LuoJianghua Shao
Oct 6, 2017·Oncotarget·Haibing YuPaul Yao
Aug 28, 2016·Oncotarget·Ilaria LaurenzanaLuigi Del Vecchio
Mar 18, 2017·Leukemia & Lymphoma·Yi ChenJianda Hu
Apr 12, 2019·FEBS Open Bio·Hongyan ChenBohan Cheng
Oct 16, 2016·Journal of Hematology & Oncology·Xi-Wen BiLiang Wang
Dec 14, 2018·Leukemia·Rou-Jun PengJin-Xin Bei
May 30, 2019·Frontiers in Oncology·Qingqing CaiKen H Young
Jul 3, 2019·Frontiers in Oncology·Mei Mei, Mingzhi Zhang
Mar 5, 2020·Therapeutic Advances in Medical Oncology·Can KüçükHua You
Oct 4, 2015·Current Hematologic Malignancy Reports·Mamiko Sakata-Yanagimoto, Shigeru Chiba
Jun 29, 2016·Oncology Reports·Wenxiu YangLingling Wang
Jul 26, 2016·Experimental and Therapeutic Medicine·Hua YangYuren Xi
Oct 20, 2020·Infectious Agents and Cancer·J CharostadE Faghihloo
May 29, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·YingYu ZhangJunQi Niu
Nov 27, 2020·Experimental and Molecular Pathology·Chih-Chi ChouWan-Ting Huang
Nov 22, 2020·Cancers·Sreevidya SanthaFengzhi Li
Dec 31, 2020·Signal Transduction and Targeted Therapy·Jun CaiQingqing Cai
Oct 17, 2020·Cancer Management and Research·Mei ZengYan Liu
Apr 4, 2021·Cancers·Ivonne A Montes-MojarroLeticia Quintanilla-Martinez
Mar 17, 2019·Experimental and Molecular Pathology·Mario Alejandro LorenzettiMaría Victoria Preciado