Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord

Development
Yu-Qiang DingZhou-Feng Chen

Abstract

The differentiation and migration of superficial dorsal horn neurons and subsequent ingrowth of cutaneous afferents are crucial events in the formation of somatosensory circuitry in the dorsal spinal cord. We report that the differentiation and migration of the superficial dorsal horn neurons are regulated by the LIM homeobox gene Lmx1b, and its downstream targets Rnx and Drg11, two transcription factors implicated in the development of dorsal horn circuitry. An analysis of Lmx1b mutants shows that Lmx1b normally acts to maintain the expression of the Ebf genes and to repress the Zic genes. Lmx1b mutants also exhibit the disruption of the cutaneous afferent ingrowth, suggesting that the dorsal horn cells might provide important cues guiding sensory axons into the dorsal spinal cord. Our results thus indicate that Lmx1b has a pivotal role in genetic cascades that control the assembly of circuitry in the superficial dorsal horn.

References

Jun 1, 1979·Journal of Neurocytology·S N Lawson, T J Biscoe
Dec 22, 1978·Brain Research·H O Nornes, M Carry
Sep 1, 1991·Journal of Neuroscience Research·M E GoldsteinH Gainer
Jun 1, 1986·The Journal of Cell Biology·S A LewisN J Cowan
Mar 1, 1970·Journal of Neurophysiology·B N Christensen, E R Perl
Dec 14, 1995·Nature·A VogelJ C Izpisúa Belmonte
Apr 21, 1994·Nature·C W RobertsS J Korsmeyer
Jan 12, 1996·The Journal of Biological Chemistry·J ArugaK Mikoshiba
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Aug 22, 1997·Cell·A L KolodkinD D Ginty
Dec 6, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S GarelP Charnay
Apr 15, 1999·Annual Review of Neuroscience·K J Lee, T M Jessell
Oct 16, 1999·Cell·T TakahashiS M Strittmatter
Feb 19, 2000·Current Opinion in Neurobiology·K Brose, M Tessier-Lavigne
Jun 8, 2001·Neuron·N A BerminghamH Y Zoghbi
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Jan 11, 2002·Developmental Biology·T Saito, N Nakatsuji
Jul 9, 2002·Current Opinion in Genetics & Development·Jean-François Brunet, Alexandre Pattyn
Aug 30, 2002·Current Opinion in Genetics & Development·Kit WongYi Rao
Feb 21, 2003·Current Opinion in Neurobiology·Amy W Helms, Jane E Johnson
Apr 3, 2003·Nature Reviews. Neuroscience·Tamara Caspary, Kathryn V Anderson
Aug 5, 2003·Nature Neuroscience·Yu-Qiang DingZhou-Feng Chen
Oct 24, 2003·Development·Mario Garcia-DominguezPatrick Charnay
Jun 1, 1952·The Journal of Comparative Neurology·B REXED

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Citations

Apr 5, 2007·Nature Protocols·Tetsuichiro Saito
Jun 2, 2005·European Journal of Human Genetics : EJHG·Ernie M H F BongersNine V A M Knoers
Apr 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jan C HolstegeJacqueline Deschamps
Dec 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Fabien D'AutréauxJean-François Brunet
Mar 24, 2006·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Katharine E Lewis
Mar 17, 2005·Genes & Development·Thomas MüllerCarmen Birchmeier
Feb 19, 2009·Development, Growth & Differentiation·Jin-Xia DaiYu-Qiang Ding
Sep 5, 2008·PloS One·Chrissa Kioussi, Michael K Gross
Nov 8, 2014·International Journal of Molecular Sciences·Shujuan JiangYanyan Zhao
Mar 9, 2010·Brain Research Bulletin·Zhi-Rong LiuYu-Qiang Ding
Dec 30, 2008·Brain Research Bulletin·Hui-Li ZouYu-Qiang Ding
Sep 6, 2008·Molecular and Cellular Neurosciences·Ming ShiYu-Qiang Ding
Sep 7, 2005·Clinical Genetics·E M H F BongersN V A M Knoers
Jul 6, 2005·Annals of Human Genetics·I McIntoshE Sweeney
Sep 30, 2005·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Anita JohnStefan Britsch
May 31, 2008·The Journal of Comparative Neurology·Jin-Xia DaiYu-Qiang Ding
Nov 30, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Kambiz N AlavianHorst H Simon
Jul 28, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takahiko J FujimiJun Aruga
Mar 3, 2007·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Christa S Merzdorf
Mar 21, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Dayana Krawchuk, Artur Kania
Jul 1, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Wendy X W Gu, Artur Kania
Jun 25, 2010·The Journal of Comparative Neurology·Steve DavidsonGlenn J Giesler
May 27, 2010·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sandra RebeloDeolinda Lima
Sep 19, 2006·Molecular and Cellular Neurosciences·Sandra RebeloDeolinda Lima
Sep 6, 2005·Brain Research. Developmental Brain Research·Matthew A AbbottChristopher K Tuggle
Feb 26, 2014·The Biochemical Journal·Ricardo Soares-dos-ReisCarlos Reguenga
Jul 3, 2015·Frontiers in Molecular Neuroscience·Daniel C LuWilliam A Alaynick
Jun 7, 2005·Developmental Biology·Leigh Wilson, Malcolm Maden
Dec 25, 2007·Developmental Biology·Catherine A RottkampStephen O'Gorman
Jan 15, 2008·Developmental Biology·Gina E ElsenVictoria E Prince
Aug 25, 2016·Neural Development·William C HilinskiKatharine E Lewis

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