Abstract
Chordoma is a rare bone cancer originating from embryologic notochordal remnants. Clival chordomas show different dural penetration ability, with serious dural penetration exhibiting poorer prognosis. The molecular mechanism of dural penetration is not clear. We analyzed lncRNA and mRNA profiles in 12 chordoma patients with different degrees of dural penetration using expression microarrays. The differentially expressed lncRNAs and mRNAs were used to construct a lncRNA-mRNA co-expression network. LncRNAs were classified into lincRNA, enhancer-like lncRNA, or antisense lncRNA. Biological functions for lncRNAs were predicted according to the lncRNA-mRNA network and adjacent coding genes by pathway analysis. The 2760 lncRNAs and 3988 mRNAs were differentially expressed in chordomas between two groups of patients with and without dural penetration. Possible pathway involvement of the significance among the 55 lncRNAs located in the lncRNA-mRNA network, 24 lincRNAs, 7 enhancer-like lncRNAs, and 14 antisense lncRNAs include cell adhesion, metastasis, invasion, proliferation, and apoptosis. Expression of 10 lncRNAs and mRNAs, and epidermal growth factor mRNA with two identified lncRNAs were subsequently verified by qRT-PCR in chordoma...Continue Reading
References
Jun 6, 2000·International Journal of Radiation Oncology, Biology, Physics·J DebusM Wannenmacher
Mar 3, 2001·Cancer Causes & Control : CCC·M L McMasterD M Parry
Aug 22, 2002·Neurosurgery·M Levent DenizM Necmettin Pamir
Apr 23, 2003·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Georges NoëlJean-Jacques Mazeron
Apr 20, 2004·Critical Reviews in Oncology/hematology·Amar BennasrounePierre Hubert
Sep 17, 2004·Cancer·Paolo G CasaliSilvana Pilotti
Oct 19, 2004·American Journal of Clinical Pathology·Jeffrey S RossGabriel N Hortobagyi
May 24, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rashmi ChughLaurence H Baker
Sep 6, 2005·Science·S KatayamaUNKNOWN FANTOM Consortium
Jan 5, 2007·Onkologie·Holger HofJürgen Debus
Oct 9, 2007·Nature Genetics·Miguel Angel PujanaMarc Vidal
Nov 2, 2007·Neuropathology and Applied Neurobiology·J H FasigJ M M Cates
Dec 7, 2007·The Oncologist·Rashmi ChughLaurence H Baker
Oct 5, 2010·Cell·Ulf Andersson ØromRamin Shiekhattar
Oct 12, 2010·RNA Biology·Tiffany Hung, Howard Y Chang
Jan 21, 2011·Nucleic Acids Research·Qi LiaoYi Zhao
Sep 6, 2011·Genes & Development·Moran N CabiliJohn L Rinn
Sep 8, 2012·Genome Research·Thomas DerrienRoderic Guigó
Jan 20, 2015·Nature Genetics·Matthew K IyerArul M Chinnaiyan
Aug 11, 2016·World Neurosurgery·Yixuan ZhaiYazhuo Zhang
Jul 14, 2017·Cancer Research·Arunoday BhanSubhrangsu S Mandal
Oct 1, 2017·Cell Proliferation·Xianli MaXuewei Xia
Jan 20, 2018·Oncotarget·Hao ChenKangwu Chen