LncRNA BANCR promotes tumorigenesis and enhances adriamycin resistance in colorectal cancer

Aging
Siping MaRui Zhang

Abstract

Colorectal cancer (CRC) is the third most common malignancy in the United States. Chemotherapeutic resistance is a massive obstacle for cancer treatment. The roles and molecular basis of long non-coding RNA BRAF-activated noncoding RNA (BANCR) in CRC progression and adriamycin (ADR) resistance have not been extensively identified. In this study, we found that BANCR and CSE1L expressions were upregulated in CRC tumor tissues. Meanwhile, CSE1L expression was correlated with depth of CRC. BANCR silencing suppressed cell proliferation and invasion capacity, increased apoptotic rate and potentiated cell sensitivity to ADR. CSE1L downregulation triggered a reduction of cell proliferation and invasion ability, and an increase of apoptosis rate and cell sensitivity to ADR. CSE1L overexpression attenuated si-BANCR-mediated anti-proliferation, anti-invasion and pro-apoptosis effects in CRC cells. BANCR acted as a molecular sponge of miR-203 to sequester miR-203 away from CSE1L in CRC cells, resulting in the upregulation of CSE1L expression. CSE1L knockdown inhibited expressions of DNA-repair-related proteins (53BP1 and FEN1) in HCT116 cells. BANCR knockdown also inhibited tumor growth and enhanced ADR sensitivity in CRC mice model. In co...Continue Reading

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Citations

Feb 6, 2020·Frontiers in Oncology·Qinglian HeWei Zhu
Sep 25, 2020·Asia-Pacific Journal of Clinical Oncology·Arash PoursheikhaniMohammad Amin Kerachian
Jul 1, 2020·Frontiers in Oncology·Xuejiao PengWeiqin Chang
Jul 31, 2020·BMC Medical Genomics·Arash PoursheikhaniMohammad Amin Kerachian
Jan 26, 2021·Cancer Biotherapy & Radiopharmaceuticals·Guo Dong HuangJun Xiong
Apr 16, 2021·Pathology, Research and Practice·Soudeh Ghafouri-FardMohammad Taheri
Sep 27, 2020·Pathology, Research and Practice·Hui ZhangYanli Li
Jul 3, 2021·Cancers·Paulína Pidíková, Iveta Herichová
Aug 20, 2021·Frontiers in Cell and Developmental Biology·Bashdar Mahmud HussenSoudeh Ghafouri-Fard
Aug 25, 2021·Cellular & Molecular Biology Letters·Ghazaleh Khalili-Tanha, Meysam Moghbeli

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Methods Mentioned

BETA
xenograft
transfection
flow cytometry
Protein Assay
electrophoresis
PCR

Software Mentioned

TargetScan

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