LncRNA CDKN2B-AS1 promotes tumor growth and metastasis of human hepatocellular carcinoma by targeting let-7c-5p/NAP1L1 axis.

Cancer Letters
Yuqi HuangHeping Kan

Abstract

Long non-coding RNAs (lncRNAs) show great potential as therapeutic targets in many diseases including hepatocellular carcinoma (HCC). Here, we aimed to investigate the clinical significance and function of lncRNA CDKN2B antisense RNA 1 (CDKN2B-AS1) in HCC. Here, we identified a novel oncogenic lncRNA CDKN2B-AS1, which was highly expressed in HCC and positively associated with large tumor size, microvascular invasion, high tumor grade, advanced tumor stage and reduced survival of HCC patients. CDKN2B-AS1 knockdown inhibited cell proliferation, migration and invasion, and induced G1 arrest and apoptosis of HCC cells in vitro, and CDKN2B-AS1 silencing suppressed tumor growth and metastasis of HCC in vivo. In accordance, CDKN2B-AS1 overexpression accelerated HCC cell growth and metastasis. Mechanistically, CDKN2B-AS1 promoted nucleosome assembly protein 1 like 1 (NAP1L1) expression by sponging let-7c-5p, thereby activated PI3K/AKT/mTOR signaling in HCC cells. Notably, NAP1L1 restoration abolished the effects of CDKN2B-AS1 silencing on HCC cell growth and metastasis. CDKN2B-AS1, an oncogenic lncRNA of HCC, promoted NAP1L1-mediated PI3K/AKT/mTOR signaling by acting as a molecular sponge of let-7c-5p. Our findings indicate that CDKN2B...Continue Reading

Citations

Nov 16, 2018·Journal of Toxicology and Environmental Health. Part a·Cong WenFei Yang
Sep 24, 2019·Journal of Cellular Biochemistry·Yiping ZhuXiaoping Qian
Dec 12, 2018·Journal of Cellular Physiology·Jing WangWeifeng Lu
Sep 10, 2019·Journal of Toxicology and Environmental Health. Part a·Jihua NieJian Tong
Nov 15, 2019·Journal of Toxicology and Environmental Health. Part a·Ming ZhangZhi-Ying Zhao
Aug 28, 2020·World Journal of Gastroenterology : WJG·Zhao-Shan NiuLi-Mei-Li Tian
Jul 28, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Ling ZhangJiumao Lin
Jan 18, 2020·In Vitro Cellular & Developmental Biology. Animal·Daokun Gui, Hanqi Cao
Aug 6, 2020·OncoTargets and Therapy·Zhenchang WangXiaojin Yang
Nov 24, 2019·Journal of Cancer Research and Clinical Oncology·Rui ZhangShi-Yao Chen
Nov 23, 2019·Cancer Cell International·Zhiqiao ZhangJianqiang Ding
Dec 8, 2020·Journal of Receptor and Signal Transduction Research·Abulaiti AbulaAihemaitijiang Yusufu
Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
Oct 17, 2020·Cancer Cell International·Gang XuZhong-Tao Zhang
Oct 6, 2020·Biochemical and Biophysical Research Communications·Xiufen ZhangLihua Li
Dec 16, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lei ZhangKangsheng Tu
Apr 4, 2021·International Journal of Molecular Sciences·Lok-Sze Wong, Chun-Ming Wong
Sep 5, 2020·Burns : Journal of the International Society for Burn Injuries·Weiwei YuanLi Yu
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri

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