LncRNA DGCR5 represses the development of hepatocellular carcinoma by targeting the miR-346/KLF14 axis

Journal of Cellular Physiology
Yu-Gang WangFa-Xiang Chen

Abstract

Long non-coding RNAs (lncRNAs) are a class of regulatory noncoding RNAs. Emerging evidence highlights the critical roles of lncRNAs in the progression of hepatocellular carcinoma (HCC). Although many lncRNAs have been identified in the development of HCC, the association between DiGeorge syndrome critical region gene 5 (DGCR5) and HCC remains unclear. In the current study, we focused on the biological role of DGCR5 in HCC. We observed that DGCR5 was decreased in HCC cells, including SMCC7721, Hep3B, HepG2, MHCC-97L, MHCC-97H, and SNU449 hepatocellular carcinoma cells, compared with the normal human liver cell line THLE-3 normal human liver cells. In addition, DGCR5 overexpression could repress HCC cell growth, migration, and invasion considerably. Increasing studies have indicated the interactions between lncRNAs and microRNAs. MicroRNAs are endogenous small noncoding RNAs and they can play important roles in tumorigenesis. MicroRNA 346 (miR-346) has been demonstrated in various human cancer types, including HCC. MiR-346 was found to be increased in HCC cells and DGCR5 can act as a sponge of miR-346 to modulate the progression of HCC. The binding correlation between DGCR5 and miR-346 was validated in our research. Subsequently,...Continue Reading

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Citations

Dec 7, 2019·Cancer Cell International·Yangyang LiXiaoming Lu
Aug 18, 2020·Journal of Experimental & Clinical Cancer Research : CR·Zhen LiXiaoming Gu
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
May 26, 2021·Journal of Neuroscience Research·Xiaoping TanShuyan Cong
Jul 30, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Haoming XiaYunfu Cui

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