LncRNA expression profile reveals the potential role of lncRNAs in gastric carcinogenesis

Cancer Biomarkers : Section a of Disease Markers
Wei GuMeijie Hu

Abstract

Gastric cancer ranks the second highest death rate and is the highest morbidity digestive system malignancy in China. Few reports have elucidated the role of long non-coding RNAs (lncRNAs) in the gastric cancer pathogenesis. The present study was aimed to identify aberrantly expressed lncRNAs involved in the progression of gastric cancer and explored their potential functions. A total of 1,297 lncRNAs and 2,037 mRNAs that showed significantly differential expression level between gastric tumor samples and matched adjacent normal tissues were identified in six pairs of samples using microarray assay. To further explore their functions, lncRNAs were classified into different subgroups and mRNAs were clustered into several pathways. The expression level of 4 lncRNAs: UCA1, lincRNA-BBOX1-2, CR594506 and BC015134 were further confirmed in another cohort of 10 gastric patients by real-time PCR assay. A coding-non-coding co-expression network revealed that the four validated lncRNAs were correlated with twenty-six mRNAs which gave clues about the potential roles of these lncRNAs in the process of gastric cancer progression.

Citations

Apr 14, 2016·Epigenomics·Michael SandSchapoor Hessam
Oct 27, 2015·World Journal of Gastroenterology : WJG·Qing YangLei Ding
Oct 4, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Qun FangXuTing Zhi
Jul 14, 2017·Cancer Research·Arunoday BhanSubhrangsu S Mandal
Mar 7, 2021·International Journal of Molecular Sciences·Carolina MathiasJaqueline C de Oliveira
Aug 21, 2021·The Kaohsiung Journal of Medical Sciences·Jian ZhangNian Yang

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