LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca2+-FAK signal pathway.

Cell Death & Disease
Ke Pan, Yong Xie

Abstract

Long noncoding RNAs (lncRNAs) have been confirmed, which are involved in tumorigenesis and metastasis in colorectal cancer (CRC). FOXC2 antisense RNA 1 (FOXC2-AS1) was reported, facilitating the proliferation and progression in several cancers. However, the role of FOXC2-AS1 in CRC cell migration and metastasis is not unclear. In this study, we observed that lncRNA FOXC2-AS1 was upregulated in CRC tissues, and its high expression indicated the poor survival in CRC patients. Meanwhile, FOXC2-AS1 was higher in CRC tissues with metastasis than that of nonmetastatic tumor tissues. We found that FOXC2-AS1 was predominately expressed in the nucleus of tissues and cells. FOXC2-AS1 knockdown suppressed CRC cell growth, invasion, and metastasis in vitro and in vivo. Moreover, FOXC2-AS1 could positively regulate the neighboring gene FOXC2 and stabilized FOXC2 mRNA by forming a RNA duplex. Meanwhile, ectopic expression of FOXC2 could obviously alleviate the suppressed effects caused by silencing FOXC2-AS1. For the mechanism, FOXC2-AS1 knockdown could reduce intracellular Ca2+ levels, inhibited FA formation and FAK signaling, and these suppressed effects were mitigated by increasing FOXC2 expression. These results demonstrated that FOXC2-A...Continue Reading

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Citations

Mar 16, 2021·Frontiers in Oncology·Zhiming LiaoChunlin Ou
Apr 16, 2021·Pathology, Research and Practice·Soudeh Ghafouri-FardMohammad Taheri
Apr 17, 2021·Journal of the Association for Research in Otolaryngology : JARO·Tomomi Yamamoto-FukudaHiromi Kojima
Aug 7, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Cuiting ChenHan Zou
Aug 16, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Ganesh Kumar BarikBhargab Kalita
Aug 25, 2021·Cellular & Molecular Biology Letters·Ghazaleh Khalili-Tanha, Meysam Moghbeli
Dec 11, 2021·Briefings in Bioinformatics·Eun-Gyeong ParkJin-Wu Nam

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Datasets Mentioned

BETA
GSE75050

Methods Mentioned

BETA
transfection
xenografts
xenograft
pull-down
flow cytometry
pulldown

Software Mentioned

SPSS
GSEA

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