lncRNA Ftx promotes aerobic glycolysis and tumor progression through the PPARγ pathway in hepatocellular carcinoma

International Journal of Oncology
Xiao LiChengyong Qin

Abstract

Aerobic glycolysis is a phenomenon by which malignant cells preferentially metabolize glucose through the glycolytic pathway, rather than oxidative phosphorylation to proliferate efficiently. The present study aimed to investigate the expression and functional implications of long non-coding (lnc)RNA Ftx in the aerobic glycolysis and tumorigenesis of hepatocellular carcinoma (HCC). It was identified that lncRNA Ftx was upregulated in human HCC tissues and cell lines and, notably, was associated with aggressive clinicopathological features. lncRNA Ftx overexpression promoted the proliferation, invasion and migration of HCC cells, whereas lncRNA Ftx knockdown resulted in the opposite effects. Furthermore, lncRNA Ftx affected the activity and expression of key enzymes in carbohydrate metabolism, suggesting that lncRNA Ftx may be involved in aerobic glycolysis in HCC. The measurement of glucose consumption, lactate production and glucose transporter expression further supported this assumption. Mechanistically, peroxisome proliferator-activated receptor γ (PPARγ) expression in human HCC tissues and cell lines was positively correlated with lncRNA Ftx. Inhibiting PPARγ in Huh7 cells partially abrogated the alterations in glucose upt...Continue Reading

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Citations

Jul 8, 2020·Journal of Experimental & Clinical Cancer Research : CR·Jiao FengChuanyong Guo
Aug 9, 2019·Cell & Bioscience·Ze ZhangFangfang Chen
Dec 19, 2019·Frontiers in Oncology·Wei LuJie Ma
Aug 9, 2020·Frontiers in Endocrinology·Tie-Ning ZhangChun-Feng Liu
Oct 31, 2020·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
Mar 4, 2021·Cancers·Amar BalihodzicMartin Pichler
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri

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Methods Mentioned

BETA
surgical resection
transfections
protein assay
PCR
Assay
transfection

Software Mentioned

GraphPad Prism
BLASTn
ImageJ
SPSS

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