lncRNA GAS8-AS1 genetic alterations in papillary thyroid carcinoma and their clinical significance.

Cancer Biomarkers : Section a of Disease Markers
Da-Lei ZhouCai-Yun He

Abstract

The long non-coding RNA (lncRNA) GAS8-AS1 is the second-most frequently altered gene, following the BRAF gene, in papillary thyroid carcinoma (PTC). We aimed to study the specificity and significance of genetic alterations in GAS8-AS1 in PTC. In this study, we reported the prevalence of genetic alterations of GAS8-AS1 in tissues of 48 nodular goiter, 573 papillary thyroid cancer, 95 colorectal cancer, 101 non-small cell lung cancer, 92 glioma, and 69 gastrointestinal stromal tumor patients, and in peripheral white blood cells of 286 healthy volunteers. We observed that the genomic sequence of GAS8-AS1 had a high frequency of genetic alterations in addition to the previously reported c.713A>G/714T>C substitution. Substitution of c.713A>G was completely linked with four other loci at c.714T>C, c.728A>G, c.737G>A, and c.752G>A. Two novel substitutions at c.749G>A and c.826A>G were also found. Interestingly, evidence from different samples indicated that these variations were not unique variants for PTC; they were also found in other malignant tissues and white blood cells of healthy volunteers. The c.713A>G substitution was associated with the T stage of PTC, while c.749G>A was more likely to occur in younger patients with PTC. PT...Continue Reading

References

Jul 27, 2006·The Journal of Clinical Endocrinology and Metabolism·K BoelaertJ A Franklyn
Sep 1, 2011·Nature Reviews. Endocrinology·Yuri E Nikiforov, Marina N Nikiforova
Apr 4, 2015·Cancer Biomarkers : Section a of Disease Markers·Mosin S KhanSyed Mudassar
Jul 16, 2016·Nature Reviews. Endocrinology·Cari M Kitahara, Julie A Sosa
Aug 7, 2017·International Journal of Endocrinology·Dongxue ZhangZhenwen Chen
Nov 24, 2018·Pathology Oncology Research : POR·Mosin S KhanSyed Mudassar

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Citations

Apr 1, 2021·Seminars in Cancer Biology·Rui-Xin LinHong Zhang

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