LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc

Nature Communications
Jiayin TangJing-Yuan Fang

Abstract

Long non-coding RNAs (lncRNAs) contribute to colorectal cancer (CRC). However, the role of lncRNAs in CRC metabolism, especially glucose metabolism remains largely unknown. In this study, we identify a lncRNA, GLCC1, which is significantly upregulated under glucose starvation in CRC cells, supporting cell survival and proliferation by enhancing glycolysis. Mechanistically, GLCC1 stabilizes c-Myc transcriptional factor from ubiquitination by direct interaction with HSP90 chaperon and further specifies the transcriptional modification pattern on c-Myc target genes, such as LDHA, consequently reprogram glycolytic metabolism for CRC proliferation. Clinically, GLCC1 is associated with tumorigenesis, tumor size and predicts poor prognosis. Thus, GLCC1 is mechanistically, functionally, and clinically oncogenic in colorectal cancer. Targeting GLCC1 and its pathway may be meaningful for treating patients with colorectal cancer.

References

Jun 24, 1997·Proceedings of the National Academy of Sciences of the United States of America·H ShimC V Dang
Aug 17, 2001·The Journal of Biological Chemistry·Y PengJ Chen
Feb 24, 1956·Science·O WARBURG
May 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·Markus WelckerBruce E Clurman
Nov 2, 2004·Nature Reviews. Cancer·Robert A Gatenby, Robert J Gillies
Jun 15, 2005·Journal of Proteome Research·Tianyi WangXian Chen
Jun 18, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Udai BanerjiIan Judson
Sep 22, 2005·Nature Reviews. Cancer·Luke Whitesell, Susan L Lindquist
Apr 5, 2007·Nature Protocols·Andrej ShevchenkoMatthias Mann
Jun 15, 2007·Nature Cell Biology·Nikita PopovMartin Eilers
Feb 23, 2008·The Biochemical Journal·Laurence H PearlPaul Workman
Sep 19, 2008·Genome Biology·Yong ZhangX Shirley Liu
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federica Di NicolantonioAlberto Bardelli
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Feb 26, 2009·Cell·Chris P PontingWolf Reik
Sep 10, 2009·Journal of the National Cancer Institute·Salvatore SienaAlberto Bardelli
Oct 3, 2009·PLoS Genetics·Chia Huey OoiPatrick Tan
Jan 25, 2011·Journal of Proteome Research·Jürgen CoxMatthias Mann
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 17, 2011·Lancet·Matthew T SeymourUNKNOWN National Cancer Research Institute Colorectal Cancer Clinical Studies Group
Jul 31, 2013·The Lancet Oncology·Rocio Garcia-CarboneroLuis Paz-Ares
Sep 4, 2013·The Journal of Clinical Investigation·Joanne R Doherty, John L Cleveland
Sep 6, 2013·Cancer Cell International·Yasumasa KatoYuh Baba
Sep 28, 2014·Bioinformatics·Simon AndersWolfgang Huber
Jul 29, 2015·Gastroenterology·John M Carethers, Barbara H Jung
Nov 20, 2016·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Abhishek BhandariSamir Gupta
Aug 30, 2017·Proceedings of the National Academy of Sciences of the United States of America·Kiyotoshi SatohTomoyoshi Soga

❮ Previous
Next ❯

Citations

Apr 3, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G XuK Zhu
Aug 9, 2020·Frontiers in Endocrinology·Tie-Ning ZhangChun-Feng Liu
Oct 3, 2020·Molecular Cancer·Tianshui SunQing Yang
Apr 9, 2020·Frontiers in Oncology·Patrick ConnertyCharles E de Bock
Aug 30, 2020·Biomedicines·Marco VacanteAntonio Biondi
Nov 12, 2020·Cancer Communications·Zhenye TangJinfang Zhang
Aug 23, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Wei LiZhaoling Cheng
Jan 26, 2021·Frontiers in Molecular Biosciences·Du CaiFeng Gao
Oct 31, 2020·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
Jan 1, 2021·Cancer Management and Research·Yutong XingJie Jiang
Feb 20, 2021·Signal Transduction and Targeted Therapy·Tingting YanJing-Yuan Fang
Mar 7, 2021·International Journal of Molecular Sciences·Abdelrahman M ElsayedCristian Rodriguez-Aguayo
Mar 4, 2021·Cancers·Amar BalihodzicMartin Pichler
Mar 12, 2021·Wiley Interdisciplinary Reviews. RNA·J J David HoPhilip A Marsden
Apr 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Fang ZhangXin Ye
Nov 8, 2020·Seminars in Cancer Biology·Rongfu TuGuoliang Qing
Mar 30, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yongcan XuMing Sun

❮ Previous
Next ❯

Datasets Mentioned

BETA
AF339830
GSE119866
GSE31737

Methods Mentioned

BETA
ubiquitination
PCR
RNA-seq
transfection
xenograft
pull-down
immunoprecipitation
Co-IP
ChIP
Knockdown

Software Mentioned

Xcalibur
Python package
MaxQuant
TopHat
R
Andromeda
DESeq2
HTSeq
GSEA
Exactive

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.