LncRNA H19 functions as an Aquaporin 1 competitive endogenous RNA to regulate microRNA-874 expression in LPS sepsis

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yu FangLimin Sun

Abstract

Sepsis is a whole-body inflammation disease after severe trauma, burn injury, infection and major surgeries, accompanied by multiple organs failure. We sought to investigate the potential mechanism of Aquaporin 1 (AQP1), miRNA-874, and lncRNA H19 in lipopolysaccharide (LPS) sepsis and the anti-inflammatory responses related to sepsis myocardial dysfunction. Serum from peripheral blood samples of sepsis patients and in vivo mice model were collected for AQP1, H19, and miR-874 expression. In vitro model in cardiomyocytes was established using LPS. H19 and miR-874 expressions were interfered in LPS induced mice and cardiomyocytes to explore the association between them and its effect on anti-inflammatory responses. H19 and AQP1 decreased and accompanied with elevated miR-874 expression in sepsis samples, in vivo mice model and in vitro cells. There was negative relationship between expression of H19 and miR-874, and a positive correlation between H19 and AQP1 expression. However, H19 overexpression transfection significantly reversed LPS induced dysregulation in expression of miR-874 and AQP1, secretion of anti-inflammatory cytokines, and myocardial dysfunction in vivo and in vitro. We determined that H19 acted as AQP1 ceRNA in re...Continue Reading

References

Aug 7, 2012·Cell Biochemistry and Function·Fang-Bao DingHao Liu
Nov 13, 2012·Journal of Cancer Research and Clinical Oncology·Feng YangGuoen Fang
Nov 30, 2012·Nucleic Acids Research·Maria D ParaskevopoulouArtemis G Hatzigeorgiou
Dec 28, 2012·Critical Care Medicine·Stephen W Bickler, Antonio De Maio
Jan 8, 2013·International Journal of Molecular Medicine·Yumei YanKun Sun
Sep 24, 2013·Molecular Cell·Amanda N KallenYingqun Huang
Feb 20, 2014·Trends in Molecular Medicine·David M Maslove, Hector R Wong
Apr 12, 2014·European Journal of Immunology·Huachun CuiGang Liu
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
Dec 3, 2014·Mayo Clinic Proceedings·Kelly A Cawcutt, Steve G Peters
Dec 23, 2014·Cell Biochemistry and Function·Sandra RiegerThomas S Lisse
Jul 15, 2015·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Xiaoying ZhouGuoxin Zhang
Oct 3, 2015·Journal of Pharmacological and Toxicological Methods·Hai-Ming TangGregory S Friedrichs
Jan 26, 2016·Biochemical and Biophysical Research Communications·Hongwei WuZhenguang Li

❮ Previous
Next ❯

Citations

Apr 3, 2020·The Journal of International Medical Research·Li WangJiang Duan
Feb 19, 2020·Current Opinion in Cardiology·Joseph B Moore, Shizuka Uchida
Apr 3, 2020·Combinatorial Chemistry & High Throughput Screening·Ling LiuRui Chen
Aug 14, 2020·Journal of Cellular Biochemistry·Yingzhou ShiYueliang Shen
Mar 30, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Huai-Rong WangXuan Song
Apr 11, 2020·Molecular Medicine·Jing WangBangwei Cao
Jan 26, 2021·Briefings in Functional Genomics·Partha ChattopadhyayRajesh Pandey
Jan 6, 2021·International Journal of Molecular Sciences·Alice Chiara ManettiVittorio Fineschi
May 29, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xin WangLi-Jie Qin
May 28, 2021·Frontiers in Cardiovascular Medicine·Jiawen LiYifei Li
Jun 1, 2021·Frontiers in Cellular and Infection Microbiology·Wei WangTie-Ning Zhang
Aug 14, 2021·Experimental Cell Research·Furong LuYiming Shao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

© 2022 Meta ULC. All rights reserved