Abstract
Studies have found that Lnc-HCG11 is an important regulator of cancer. However, the function of Lnc-HCG11 in NSCLC is not known. Therefore, this experimental design was based on Lnc-HCG11 to explore the pathogenesis of NSCLC. RT-qPCR was used to detect the expression of Lnc-HCG11 and miR-224-3p in NSCLC. The effects of Lnc-HCG11 and miR-224-3p on proliferation and apoptosis of NSCLC cells were detected by CCK-8 assay, Edu assay and Annexin V-FITC/PI assay. Target gene prediction and screening, luciferase reporter assays were used to verify downstream target genes for lnc-HCG11 and miR-224-3p. Western blotting was used to detect the protein expression of caspase-3. The tumor changes in mice were detected by in vivo. Lnc-HCG11 was significantly reduced in NSCLC. Lnc-HCG11 significantly inhibited cell proliferation of NSCLC cells and induced apoptosis. miR-224-3p was significantly elevated in the NSCLC cell line. Moreover, miR-224-3p significantly increased cell proliferation and inhibited apoptosis of NSCLC cells. Furthermore, Lnc-HCG11 was negatively correlated with miR-224-3p expression. Lnc-HCG11 over-expression was up-regulated the expression levels of c-caspase-3 and caspase-3. Finally, the results of in vivo animal models c...Continue Reading
References
Sep 4, 1998·Cell·H LiJ Yuan
Oct 29, 2010·The New England Journal of Medicine·Eunice L KwakA John Iafrate
Jul 6, 2014·The FEBS Journal·Miaojun ZhuJianxiu Yu
Jul 16, 2014·Oncology Reports·Henan ZhaoYan Wang
Oct 29, 2015·Cancer Science·Akira KurozumiNaohiko Seki
Dec 25, 2015·Gene·Xiaobin FengLi Jia
Oct 25, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yalong ZhangYao Li
Oct 1, 2016·Oncotarget·Shuyao TangXueying Sun
Nov 20, 2016·Cell Biochemistry and Function·Su JiliZhang Chao
Nov 30, 2016·Scientific Reports·Shasha LiuPengpeng Qu
Jan 9, 2017·Biochimica Et Biophysica Acta. Molecular Cell Research·Tatiana F SergeevaElena V Zagaynova
Jan 15, 2017·Oncotarget·Bei SunLiming Chen
Jul 6, 2017·International Journal of Oncology·Yantian XuTao Li
May 1, 2012·Thoracic Cancer·Qiong HuCaiCun Zhou
Oct 3, 2017·Cancer Letters·Bowen LiZekuan Xu
Jan 25, 2018·Nature·Roy S HerbstChris Boshoff
Feb 1, 2018·Therapeutic Advances in Medical Oncology·Irene Moya-HornoRafael Rosell
Mar 6, 2018·Current Geriatrics Reports·Nicolaas I BohnenStefan J Teipel
Mar 11, 2018·International Journal of Cancer. Journal International Du Cancer·Min ZhouChuan-Yuan Li
Jun 12, 2018·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Xiaxia WangShanglang Cai
Jul 5, 2018·Journal of Experimental & Clinical Cancer Research : CR·Haicheng TangJianan Huang
Aug 16, 2018·Nature Reviews. Molecular Cell Biology·Luca F R Gebert, Ian J MacRae
Oct 8, 2018·Analytica Chimica Acta·Teresa W M FanAndrew N Lane
Citations
Apr 16, 2021·Cancer Management and Research·Shenni YiXiuhong Chu
Aug 10, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMajid Mokhtari
Nov 16, 2021·Molecular and Cellular Biology·Yin DuanXiao-Ai Lv