lncRNA LEF1-AS1 Promotes Malignancy in Non-Small-Cell Lung Cancer by Modulating the miR-489/SOX4 Axis

DNA and Cell Biology
Jiansheng YangLiangan Lin

Abstract

Increasing evidence has indicated that long noncoding RNAs (lncRNAs) could participate in diverse cancers. Among these, lymphoid enhancer-binding factor 1 antisense RNA 1 (LEF1-AS1) was recently identified as an oncogenic lncRNA, but little is known about its function in non-small-cell lung cancer (NSCLC). In the present study, we found that LEF1-AS1 was markedly upregulated in lung cancer tissues and could promote NSCLC cell proliferation and migration in vivo and in vitro. LEF1-AS1 could bind with miR-489 and further negatively regulate miR-489 to promote SRY-related HMG box transcription factor 4 (SOX4) expression. In conclusion, these data suggested that LEF1-AS1 promoted NSCLC tumorigenesis dependent on the miR-489-SOX4 axis and implicated the potential application of LEF1-AS1 for the prognosis and treatment of NSCLC.

References

May 16, 2013·American Journal of Respiratory Cell and Molecular Biology·Philip ThaiReen Wu
Jun 12, 2013·The International Journal of Biochemistry & Cell Biology·Chi Han Li, Yangchao Chen
Sep 28, 2013·Cancer Discovery·Florian A Karreth, Pier Paolo Pandolfi
Feb 4, 2014·The EMBO Journal·Keith W VanceChris P Ponting
Apr 30, 2014·Nature Reviews. Genetics·Kevin V Morris, John S Mattick
Dec 11, 2014·Journal of Hematology & Oncology·Gregory LoewenBin Shan
Apr 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zongtao XieZhiqiang Wang
Apr 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jing ZhangXiaodong Chen
Mar 24, 2016·Cellular and Molecular Life Sciences : CMLS·Sandra U SchmitzBernhard G Herrmann
Feb 7, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yang-Hua FanXin-Gen Zhu
Aug 7, 2017·Trends in Cancer·Ana Rita Lourenço, Paul J Coffer
Sep 13, 2017·OncoTargets and Therapy·Jin WangPeng Zhao

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Citations

Sep 1, 2019·Current Pharmaceutical Design·Asma VafadarHamed Mirzaei
Jul 8, 2020·Non-coding RNA·Lucy GinnMichela Garofalo
Aug 12, 2020·Molecular and Cellular Biochemistry·Yuexia WuCong Sun
Mar 1, 2020·Experimental and Molecular Pathology·Soudeh Ghafouri-FardMohammad Taheri
Jan 9, 2021·Genomics & Informatics·Danbi SeoWanyeon Kim

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Methods Mentioned

BETA
transfection
PCR
Protein Assay
Assay
immunoprecipitation
xenograft
bioluminescence imaging
RNA-Seq
flow cytometry

Software Mentioned

TargetScan

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