LncRNA MALAT1 negatively regulates MDSCs in patients with lung cancer

Journal of Cancer
Qinfeng ZhouShengjun Wang

Abstract

Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive functions and contribute to the formation of the tumor microenvironment. Long non-coding (Lnc) RNAs are highly important factors associated with tumors and may be used as markers for tumor diagnosis, which is valuable for targeted therapy. LncRNA MALAT1 is expressed in various tissues and plays a critical role in cell proliferation, including tumorigenesis and metastasis. However, the role of MALAT1 in MDSCs is unclear. In this study, we observed an increased proportion of MDSCs and elevated levels of the related molecule arginase-1 (ARG-1) in peripheral blood mononuclear cells (PBMCs) obtained from lung cancer patients. The proportion of CD8+ cytotoxic T lymphocyte (CTL) was significantly decreased in PBMCs from lung cancer patients. Moreover, the proportion of CTL cells was negatively correlated with the proportion of MDSCs. Furthermore, MALAT1 levels were decreased in PBMCs from lung cancer patients. The relative expression of MALAT1 was moderate negatively correlated with the proportion of MDSCs. In vitro results indicate that the knockdown of MALAT1 significantly increased the proportion of MDSCs. Our data provide the first evidence that lncRNA MALAT1 n...Continue Reading

Citations

Jun 27, 2019·International Journal of Immunopathology and Pharmacology·Shuquan WeiZiwen Zhao
Jul 16, 2019·Cell & Bioscience·Ying ZhangLiu Yang
Dec 28, 2019·Current Stem Cell Research & Therapy·Jicheng WangZhi Yi
Aug 14, 2019·Frontiers in Immunology·Gabriela Leija MontoyaNicolás Serafín Higuera
Feb 23, 2019·Frontiers in Immunology·Yungang WangShengjun Wang
Feb 2, 2020·Journal of Hematology & Oncology·Zhenzhen YangWang Ma
Nov 6, 2020·Journal of Experimental & Clinical Cancer Research : CR·Yalu ZhangQuan Liao
Nov 3, 2020·Frontiers in Immunology·Elham SafarzadehBehzad Baradaran
Oct 15, 2020·Journal for Immunotherapy of Cancer·Yungang WangShengjun Wang
Jun 1, 2020·Pharmacology & Therapeutics·Qingsong HuLiuqing Yang
Nov 10, 2020·Life Sciences·Md Nazim Uddin, Xiaosheng Wang
Aug 26, 2021·Technology in Cancer Research & Treatment·Peng HuangLinjiang Song
Oct 17, 2021·Journal of Hematology & Oncology·Yiyin ZhangHui Lin
Dec 11, 2021·Briefings in Bioinformatics·Eun-Gyeong ParkJin-Wu Nam

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Methods Mentioned

BETA
PMA
flow cytometry

Software Mentioned

FlowJo

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