LncRNA mediated regulation of aging pathways in Drosophila melanogaster during dietary restriction

Deying YangMingyao Yang


Dietary restriction (DR) extends lifespan in many species which is a well-known phenomenon. Long non-coding RNAs (lncRNAs) play an important role in regulation of cell senescence and important age-related signaling pathways. Here, we profiled the lncRNA and mRNA transcriptome of fruit flies at 7 day and 42 day during DR and fully-fed conditions, respectively. In general, 102 differentially expressed lncRNAs and 1406 differentially expressed coding genes were identified. Most informatively we found a large number of differentially expressed lncRNAs and their targets enriched in GO and KEGG analysis. We discovered some new aging related signaling pathways during DR, such as hippo signaling pathway-fly, phototransduction-fly and protein processing in endoplasmic reticulum etc. Novel lncRNAs XLOC_092363 and XLOC_166557 are found to be located in 10 kb upstream sequences of hairy and ems promoters, respectively. Furthermore, tissue specificity of some novel lncRNAs had been analyzed at 7 day of DR in fly head, gut and fat body. Also the silencing of lncRNA XLOC_076307 resulted in altered expression level of its targets including Gadd45 (involved in FoxO signaling pathway). Together, the results implicated many lncRNAs closely associ...Continue Reading


Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 6, 2002·The Journal of Biological Chemistry·Thomas HankelnThorsten Burmester
Apr 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jonathan L TupyGerald M Rubin
Mar 24, 2006·Nature·Ilya ShamovskyEvgeny Nudler
Feb 24, 2007·Molecular Cell·Carol J Wilusz, Jeffrey Wilusz
May 9, 2007·Nature Cell Biology·Takefumi KondoYuji Kageyama
Oct 9, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Timothy M BassMatthew D W Piper
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Apr 14, 2009·Nature·Jennifer L Mummery-WidmerJuergen A Knoblich
Jul 7, 2009·Ageing Research Reviews·Jennifer L KukRobert Ross
Jul 2, 2011·Disease Models & Mechanisms·Laura Palanker MusselmanThomas J Baranski
Dec 1, 2011·Nucleic Acids Research·Marco PuntaRobert D Finn
Jul 4, 2012·Seminars in Cell & Developmental Biology·Molly C Schroeder, Georg Halder
Apr 16, 2013·Developmental Biology·Amanda J Monahan, Michelle Starz-Gaiano
Sep 17, 2013·PloS One·Athanasios Metaxakis, Linda Partridge
Oct 2, 2013·Current Pharmaceutical Design·Gabriella TestaElena Chiarpotto
Feb 11, 2014·Neuron·A Zara Herskovits, Leonard Guarente
Mar 29, 2014·Nature·James B BrownSusan E Celniker
Dec 4, 2014·Acta Biochimica Et Biophysica Sinica·Lei Zhang
Dec 24, 2014·Journal of Molecular and Cellular Cardiology·Cristina BeltramiCostanza Emanueli
Dec 30, 2014·Aging·Ioannis GrammatikakisMyriam Gorospe
Jan 27, 2015·Medical Hypotheses·Amalia Gabriela DiaconeasaRaluca-Ioana Stefan-van Staden
Feb 2, 2015·Current Opinion in Neurobiology·Roger C Hardie, Mikko Juusola
Feb 3, 2015·Journal of Molecular and Cellular Cardiology·Simona GrecoFabio Martelli
Feb 3, 2015·Molecular Carcinogenesis·Wenting PanMing Yang
Feb 27, 2015·ELife·Brandon D BunkerDavid Bilder
Mar 27, 2015·Nature Communications·Feng HeJun Ma

❮ Previous
Next ❯


May 2, 2017·Experimental Gerontology·Chaochun SongMingyao Yang
Sep 25, 2019·International Journal of Molecular Sciences·Keqin LiDeying Yang
Feb 8, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Xiao Chun YangQian Fan
Nov 5, 2019·Frontiers in Genetics·Yue HouXiao Sun
Sep 24, 2020·Genes·Itika AroraTrygve O Tollefsbol
Jan 4, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xixi CaiShaoyun Wang

❮ Previous
Next ❯

Methods Mentioned


Software Mentioned

PhyloCSF ( substitution frequency )
Pfam Scan
GOseq R package

Related Concepts

Related Feeds

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.