LncRNA MEG3 enhances 131 I sensitivity in thyroid carcinoma via sponging miR-182

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Yang LiuXiaoqi Chen

Abstract

Long non-coding RNA (LncRNA) MEG3 has been demonstrated as a tumor suppressor in various cancers, including thyroid carcinoma (TC). However, the detail functions and possible mechanisms of MEG3 in 131I resistance of TC remain to be uncovered. qRT-PCR was performed for the detection of MEG3 and miR-182 levels. 131I-resistant TC cells were constructed by continuous exposure to stepwise increased concentrations of 131I. Western blot assay was used to measure the protein expressions of γ-H2 AX and H2 AX. CCK-8 and flow cytometry assays were carried out for the evaluation of cell viability and apoptosis, respectively. Bioinformatics and dual-luciferse assays were conducted to prove the interaction of MEG3 and miR-182. MEG3 expression was down-regulated in TC tumor tissues, and the cumulative survival rate was decreased in low MEG3 expression group in TC patients under 131I treatment. MEG3 expression appeared a decline and miR-182 expression displayed an increase in 131I-resistant FTC-133 (res-FTC-133) and TPC-1 (res-TPC-1) cells. Moreover, MEG3 overexpression suppressed 131I-resistant cell viability, promoted apoptosis and induced DNA damage. MEG3 was verified as a molecular sponge for miR-182, and inhibition of miR-182 exerted simi...Continue Reading

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Citations

Sep 20, 2018·Journal of Cellular Biochemistry·Mohammad-Taher MoradiZohreh Rahimi
Feb 23, 2019·Pathology Oncology Research : POR·Arwa Al-RugeebahNarasimha Reddy Parine
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Nov 11, 2019·Experimental and Molecular Pathology·Soudeh Ghafouri-FardMohammad Taheri

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