LncRNA NEAT1/miR-129/Bcl-2 signaling axis contributes to HDAC inhibitor tolerance in nasopharyngeal cancer.

Aging
Fei XueXia Gao

Abstract

Histone deacetylase inhibitors (HDACis) - based therapeutic drug tolerance is one of the principal factors of poor prognosis of patients with nasopharyngeal cancer (NPC). Mechanisms of tolerance to HDACis are not well understood. Nowadays, dysregulation of long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) has been reported to provide beneficial or inhibitory effects in drug-tolerance in various cancers. Herein, we established the HDAC inhibitor (SAHA)-tolerant NPC cell sublines, which had decreased apoptosis in response to SAHA treatment. We observed that the expression of miR-129 was significantly reduced in SAHA-tolerant NPC cells. Manipulating the expression of miR-129 overcame SAHA tolerance, and enhanced the SAHA-induced apoptosis. In terms of miR-129 downregulation, we identified that NEAT1 suppresses miR-129 expression. NEAT1 was found to be upregulated in SAHA tolerance cells. The depletion of NEAT1 phenocopied the effect of miR-129 overexpression, which also enhanced SAHA-induced apoptosis. Bcl-2 was the downstream target of miR-129 and contributed to SAHA tolerance in NPC. Our in vivo xenograft experiment confirmed that the administration of miR-129 or inhibition of Bcl-2 overcame the SAHA tolerance in NPC. In con...Continue Reading

References

Mar 21, 2002·Nature Reviews. Cancer·P MarksW K Kelly
Apr 30, 2002·International Journal of Cancer. Journal International Du Cancer·Astrid A RuefliRicky W Johnstone
Feb 21, 2003·International Journal of Cancer. Journal International Du Cancer·Maria D Castro-GalacheMiguel Saceda
Dec 15, 2004·Proceedings of the National Academy of Sciences of the United States of America·Yufang ShaoXuejun Jiang
Nov 30, 2005·Nucleic Acids Research·Caifu ChenKarl J Guegler
Feb 3, 2006·Cancer Research·Gary K ScottChristopher C Benz
May 18, 2007·Annual Review of Genomics and Human Genetics·Tsung-Cheng Chang, Joshua T Mendell
Dec 21, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Valeria R Fantin, Victoria M Richon
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jun 13, 2009·International Journal of Cancer. Journal International Du Cancer·Eva BandresJesus Garcia-Foncillas
Jan 29, 2011·Chinese Journal of Cancer·Su-Mei CaoChao-Nan Qian
Jan 3, 2014·The Journal of Clinical Investigation·Alison C West, Ricky W Johnstone
Apr 29, 2014·International Journal of Cancer. Journal International Du Cancer·Kwai Fung Hui, Alan K S Chiang
Mar 10, 2015·Critical Reviews in Oncogenesis·Hong Ping ChenTing C Zhao
May 11, 2015·The Lancet Oncology·Pierre BlanchardUNKNOWN MAC-NPC Collaborative Group
Sep 1, 2015·Lancet·Melvin L K ChuaAnthony T C Chan
Sep 8, 2016·Cold Spring Harbor Perspectives in Medicine·Yixuan Li, Edward Seto
Jan 21, 2017·Cell Proliferation·Xin YuWilliam Ka Kei Wu
May 21, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Luo FangPing Huang
Jul 22, 2017·Science·William A FlavahanBradley E Bernstein
Aug 28, 2018·Journal of Cellular Physiology·Mehri GhasabiBehzad Baradaran
Feb 13, 2019·Clinical Epigenetics·Wengong SiWeimin Fan
Mar 11, 2019·Molecular Therapy : the Journal of the American Society of Gene Therapy·Weijian SunXian Shen

❮ Previous
Next ❯

Citations

Mar 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bashdar Mahmud HussenSoudeh Ghafouri-Fard
Jul 3, 2021·Journal of Personalized Medicine·Zheng ZhangYan-Ru Lou

❮ Previous
Next ❯

Methods Mentioned

BETA
acetylation
flow cytometry
transfection
biopsies
PCR

Software Mentioned

RNAhybrid
TargetScan

Related Concepts

Related Feeds

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.