Abstract
NF-κB interacting lncRNA (NKILA) has been found to function as a tumor-suppressive role in various human cancers. However, the role of NKILA in rectal cancer is still unknown. The objective of this study is to investigate the clinical value and biological function of NKILA in rectal cancer. The association between NKILA expression and clinical variables including prognosis was estimated in rectal cancer patients. The gain-of-function study of NKILA in rectal cancer cell was conducted to evaluate the effect of NKILA on cell proliferation, migration, invasion, and NF-κB signaling pathway. The results suggested NKILA expression was decreased in rectal cancer tissues and cells, and correlated with clinical stage, T classification, N classification and M classification. NKILA low-expression was an independent poor prognostic factor in rectal cancer patients. NKILA-inhibited rectal cancer cell proliferation, migration, and invasion via suppressing NF-κB signaling. In conclusion, NKILA serves as an antioncogenic lncRNA in rectal cancer.
References
Mar 2, 2011·Cancer Causes & Control : CCC·Kristin L WhiteEllen L Goode
Mar 23, 2012·Immunological Reviews·Joseph A DiDonatoMichael Karin
Jun 25, 2014·Seminars in Immunology·Matthew S Hayden, Sankar Ghosh
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Mar 12, 2015·Cancer Cell·Bodu LiuErwei Song
Jun 13, 2015·F1000Research·Johannes M Dijkstra, David B Alexander
Oct 28, 2015·BioMed Research International·Raquel Conde-MuíñoPablo Palma
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Sep 11, 2016·Oncotarget·Wei HuangYujie Liu
Feb 2, 2017·Bioscience Reports·Run-Tian LiuHai-Tao Lv
Apr 18, 2017·Journal of Experimental & Clinical Cancer Research : CR·Zhiliang LuJie He
Apr 28, 2017·Cancer Genomics & Proteomics·Ulrich H WeidleRüdiger Rüger
Jun 22, 2017·Journal of Community Hospital Internal Medicine Perspectives·Shideh DoroudiVincent A DeBari
Aug 15, 2017·Clinical Colorectal Cancer·Aaron J FrankeThomas J George
Sep 28, 2017·International Journal of Molecular Sciences·Nagisa NosratiGopinadhan Paliyath
Sep 28, 2017·Bioscience Reports·Zhengqiang MaoShoufeng Zai
Oct 20, 2017·Bioscience Reports·Anqiang YangXiaobing Yang
Nov 21, 2017·Clinical Colorectal Cancer·Donglin DuZhengqiang Wei
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 20, 2018·Aging·Shun KeMing-Hao Fang
Jan 31, 2018·Nature Reviews. Immunology·Koji Taniguchi, Michael Karin
Jan 31, 2018·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Zhiliang LuJie He
Feb 27, 2018·Chemico-biological Interactions·Xiaolan YuJiyi Xia
Mar 4, 2018·IUBMB Life·Yongping ZhouTu Dai
Mar 20, 2018·Translational Research : the Journal of Laboratory and Clinical Medicine·Meera PatelJoanne Edwards
Mar 25, 2018·Cancer Medicine·Tao YangQinglai Tang
Citations
Jun 8, 2019·Journal of Cellular Biochemistry·Yuanbo ZhongAijun Shan
Apr 1, 2020·Chinese Medical Journal·De-Zhong WangNeng-Wei Zhang
Jul 19, 2019·Experimental and Therapeutic Medicine·Qingyong LiSuocheng Niu
Aug 28, 2020·BioMed Research International·Siyuan TianYuan Zhou
Jan 18, 2020·Journal of Cellular Physiology·Jinou WangQingjie Lv
Nov 5, 2020·Technology in Cancer Research & Treatment·Daoyong HuQun Dai
Sep 13, 2020·Journal of Ethnopharmacology·Chen ChenYu-Hui Wei
Jan 22, 2021·Molecular and Cellular Biochemistry·Ming ChenBin Zhu
Apr 11, 2021·Cancer Letters·Sepideh MirzaeiGautam Sethi
Apr 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bashdar Mahmud HussenSoudeh Ghafouri-Fard
Jul 6, 2021·Frontiers in Oncology·Changjing CaiShan Zeng
Jul 13, 2021·Frontiers in Genetics·Fuda HuangJian Pu
Jul 26, 2021·European Journal of Pharmacology·Chunyuan TangLushan Yu