lncRNA NORAD Contributes to Colorectal Cancer Progression by Inhibition of miR-202-5p.

Oncology Research
Jie ZhangYuan-Sheng Ding

Abstract

Previous study indicates that long noncoding RNA NORAD could serve as a competing endogenous RNA to pancreatic cancer metastasis. However, its role in colorectal cancer (CRC) needs to be investigated. In the present study, we found that the expression of NORAD was significantly upregulated in CRC tissues. Furthermore, the expression of NORAD was positively related with CRC metastasis and patients' poor prognosis. Knockdown of NORAD markedly inhibited CRC cell proliferation, migration, and invasion but induced cell apoptosis in vitro. In vivo experiments also indicated an inhibitory effect of NORAD on tumor growth. Mechanistically, we found that NORAD served as a competing endogenous RNA for miR-202-5p. We found that there was an inverse relationship between the expression of NORAD and miR-202-5p in CRC tissues. Moreover, overexpression of miR-202-5p in SW480 and HCT116 cells significantly inhibited cellular proliferation, migration, and invasion. Taken together, our study demonstrated that the NORAD/miR-202-5p axis plays a pivotal function on CRC progression.

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Citations

May 19, 2018·Cancer Science·Anna Sanchez CalleTakahiro Ochiya
Jul 2, 2020·Cells·Marisol Godínez-Rubí, Daniel Ortuño-Sahagún
Jul 26, 2019·The Journal of International Medical Research·Haiyan Zhang, Haixiang Guo
Oct 22, 2019·Biochemical and Biophysical Research Communications·Huimeng QiQiang Liu
Jan 14, 2021·International Journal of Molecular Sciences·Kenzui Taniue, Nobuyoshi Akimitsu
Feb 13, 2021·Biochemical Pharmacology·B BaptistaF Sousa
Mar 20, 2021·Genetics and Molecular Biology·Carolina MathiasDaniela Fiori Gradia
May 27, 2021·Transcription·K T Ramya DeviSanjana Prakash Hemdev
Nov 1, 2020·Life Sciences·Negin SoghliDurdi Qujeq
Jun 21, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Baiqi WangFengxia Mao
Dec 1, 2020·Molecular Therapy Oncolytics·Hamed Mirzaei, Michael R Hamblin
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huican HuoNing Wang

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Methods Mentioned

BETA
FACS
Assay
PCR
xenograft

Software Mentioned

Statistical Package for the Social Sciences
NORAD

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