Abstract
OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1) plays an important regulatory role in various types of cancers. However, the functional role and regulatory mechanisms of OIP5-AS1 in gastric cancer (GC) remain largely unknown. In this study, we found that the expression of OIP5-AS1 was increased in GC tissues compared with that in adjacent non-cancerous tissues, which was significantly associated with shorter overall survival time of patients. In addition, OIP5-AS1 expression was also increased in GC cell lines including NCI-N87, MKN-45, BGC-823 and SGC-7901, when compared with that in normal gastric epithelial cell line GES-1. Knockdown of OIP5-AS1 markedly suppressed the proliferation and colony formation activities of GC cells, induced G0/G1 arrest and apoptosis of GC cells in vitro, and restrained tumor growth in vivo. Mechanistically, OIP5-AS1 functions as an oncogenic competing endogenous RNA by binding to and sequestering miR-422a to elevate the expression of anoctamin-1. Our study first demonstrated that OIP5-AS1 is a critical and powerful regulator of GC pathogenesis and may represent a novel candidate target for GC therapy.
References
Nov 10, 2015·Oncogene·H YangJ Chen
Jan 29, 2016·Nucleic Acids Research·Jiyoung KimMyriam Gorospe
Feb 15, 2017·Journal of Experimental & Clinical Cancer Research : CR·Qinghua CaoLiantang Wang
Mar 21, 2017·Molecular and Cellular Biochemistry·Yanjun LaiShifang Zhuang
May 5, 2017·Molecular and Cellular Biochemistry·Shaoan ChenXunbo Jin
Aug 11, 2017·Cell Death & Disease·Nan YangWanggang Zhang
Dec 17, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun DengSongping Wang
Jan 18, 2018·Cancer Letters·Hao YuanLiang Qiao
Jan 18, 2018·Carcinogenesis·Yuqiu GeZhengdong Zhang
Feb 22, 2018·Theranostics·Xiaobai LiuYunhui Liu
Feb 22, 2018·Cancer Biotherapy & Radiopharmaceuticals·Guohao LuHongyu Zheng
Feb 24, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Ze ZhangYahui Liu
May 5, 2018·Cell Death & Disease·Zhongyuan HeZekuan Xu
May 19, 2018·European Journal of Cell Biology·Yanmei ZouHua Xiong
Jul 4, 2018·Cancer Letters·Juan GuZhimin He
Aug 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian DaiXiaoming Tang
Sep 10, 2018·Molecular Therapy. Nucleic Acids·Zhixia ZhouJianxun Wang
Sep 16, 2018·Cancer Letters·Di WuJiachun Lu
Nov 18, 2018·Gastroenterology·Wei ZhuoTianhua Zhou
Dec 6, 2018·Journal of Cellular Physiology·Qiushuang JiHailong An
Jan 31, 2019·PLoS Pathogens·Wan LiChun Lu
Feb 13, 2019·Oncogene·Li ZhangJun Yu
Mar 16, 2019·Biochemical and Biophysical Research Communications·Xiaoqing ZengShiyao Chen
Sep 10, 2019·Journal of Cellular and Molecular Medicine·Chen CaoWenneng Liu
Citations
Aug 18, 2020·OncoTargets and Therapy·Pei MaQi Zhao
Sep 15, 2020·The Journal of Gene Medicine·Hui LuLiying Liu
Jan 7, 2021·RNA Biology·Elżbieta WanowskaMichał Wojciech Szcześniak
Feb 19, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
Mar 30, 2021·Frontiers in Cell and Developmental Biology·Atsushi ShiozakiEigo Otsuji
Jun 17, 2021·Cell Biology and Toxicology·Xuan WangXiaobing Jiang
Apr 27, 2021·Bioscience Reports·Zhiping ChenLanfeng Wang