LncRNA profiling reveals new mechanism for VDR protection against skin cancer formation

The Journal of Steroid Biochemistry and Molecular Biology
Yan J Jiang, Daniel D Bikle

Abstract

Accumulating evidence strongly suggests a protective role of vitamin D signaling against chemical and UVR-induced skin cancer formation. However, the mechanism remains largely unknown. Recently, the emerging role of long, non-coding RNA (lncRNA) as a hallmark of cancer has become better appreciated. LncRNAs are mRNA-like transcripts ranging in length from 200 bases to 100kb lacking significant open reading frames, which are involved in a broad spectrum of tumorigenic/metastatic processes. In this study we profiled 90 well-annotated mouse lncRNAs from cultured mouse keratinocytes after deleting the vitamin D receptor (VDR) (∼90%) vs. control cells using an lncRNA array analysis. We found that several well-known oncogenes, including H19, HOTTIP and Nespas, are significantly increased (6.3-1.8-fold), whereas tumor suppressors (Kcnq1ot1, lincRNA-p21) are decreased (up to 50-70%) in VDR deleted keratinocytes. A similar pattern of lncRNA profiling is observed in the epidermis of K14 driven, tamoxifen-regulated epidermal-specific VDR null vs. wild-type control mice. Additionally there is an increase in the expression levels of other oncogenes (mHOTAIR, Malat1 and SRA) and a decrease of other tumor suppressors (Foxn2-as, Gtl2-as, H19-a...Continue Reading

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Citations

Aug 14, 2015·International Journal of Molecular Sciences·Sai-Sai TangXing-Dong Xiong
Nov 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fan ZhangCaiguo Zhang
Jul 28, 2016·Frontiers in Physiology·Daniel D BikleChia-Ling Tu
Apr 14, 2016·Epigenomics·Michael SandSchapoor Hessam
Dec 18, 2018·The Journal of International Medical Research·Tao YangJianghe Shao
Oct 16, 2018·Endocrine Reviews·Roger BouillonJohn Bilezikian
Apr 3, 2019·Bone Research·Andreia Machado SilvaMaria Inês Almeida
Aug 28, 2016·Molecular and Cellular Biochemistry·Krishna K SinghSubodh Verma
Dec 12, 2018·Cell & Bioscience·Hu PengJiang-Feng Wu
Oct 17, 2017·Immunology·Majid Pahlevan KakhkiMehrdad Behmanesh
Jan 27, 2016·World Journal of Gastroenterology : WJG·Juan-Fei PengShi-Neng Zhang
Apr 25, 2020·International Journal of Molecular Sciences·Young-Ah KimSun-Jae Lee
Jan 9, 2021·Genomics & Informatics·Danbi SeoWanyeon Kim

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