LncRNA PVT1 as an effective biomarker for cancer diagnosis and detection based on transcriptome data and meta-analysis

Oncotarget
Yunhong ZengDongsheng Hu

Abstract

Long noncoding RNA (lncRNA) PVT1 was detected all types of cancer from Cancer Genome Atlas (TCGA) project; however, the role of PVT1 in cancer is not clear. This study aimed to reanalyze and determine the effect of PVT1 on cancer diagnosis, especially detection in serum. Differential expression of PVT1 between cancers and corresponding normal tissues and receiver operating characteristic (ROC) curve were analyzed for all types of cancers in TCGA database. RevMan5.3, Meta-DiSc1.4 and STATA14.0 were used to estimate pooled diagnostic effects of PVT1 in tissue as well as serum. Compared to corresponding normal tissues, PVT1 expression was significantly upregulated in 18 types of cancer and further being an effective diagnosis biomarker in 16 of them. For the 23 diagnosis tests performed in tissue, the pooled AUC and diagnostic odd ratio (DOR) were estimated to be 0.81 (95% CI: 0.76-0.86) and 17.25 (95% CI: 8.43-35.27), when the pooled AUC and DOR were 0.83 (95%CI: 0.75-0.91) and 13.86 (95% CI: 4.70-40.66) for serum tests. Furthermore, the pooled sensitivity and specificity were 0.83 (95% CI: 0.76-0.89) and 0.74 (95% CI:0.70-0.84) for tissue as well as 0.81 (95% CI: 0.76-0.86) and 0.76 (95% CI:0.70-0.81) for serum. PVT1, especially...Continue Reading

References

Jul 31, 1975·The New England Journal of Medicine·T J Fagan
Nov 15, 2003·Journal of Clinical Epidemiology·Afina S GlasPatrick M M Bossuyt
May 19, 2005·Statistics in Medicine·S D Walter
Jul 14, 2006·BMC Medical Research Methodology·Javier ZamoraArri Coomarasamy
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Feb 18, 2012·Nature·Mitchell Guttman, John L Rinn
Jun 14, 2014·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Erick RiquelmeIgnacio I Wistuba
Jul 22, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fang WangShu-Han Sun
Feb 19, 2015·Contemporary Oncology Współczesna Onkologia·Katarzyna TomczakMaciej Wiznerowicz
Apr 18, 2015·BioMed Research International·Teresa ColomboPaola Paci
Aug 5, 2015·Molecular Medicine Reports·Xin Yu, Zheng Li
Oct 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qinyi ZhouJiadong Wang
Oct 23, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di CuiWei-Long Jiang
Nov 18, 2015·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·Juneyoung LeeSeong Ho Park
Jan 21, 2016·Oncotarget·Tianwen LiJunming Guo
Feb 16, 2016·International Journal of Cancer. Journal International Du Cancer·Sonam Dhamija, Sven Diederichs
Feb 19, 2016·Cell Cycle·Aaron L SarverAnindya Bagchi
Mar 24, 2016·Cellular and Molecular Life Sciences : CMLS·Sandra U SchmitzBernhard G Herrmann
Apr 1, 2015·Molecular & Cellular Oncology·Yuen-Yi Tseng, Anindya Bagchi
Aug 2, 2016·The Journal of Clinical Investigation·Joseph R EvansArul M Chinnaiyan
Nov 1, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mi-Die XuXiang Du
Jan 5, 2017·BMC Bioinformatics·Fabio CumboEmanuel Weitschek
Jan 17, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yang-Hua FanXin-Gen Zhu
Mar 8, 2017·BioMed Research International·Xiangjun ChenHao Dong
Mar 30, 2017·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Hong-Mei LiJun-Qiang Chen
Apr 28, 2017·Cancer Genomics & Proteomics·Ulrich H WeidleRüdiger Rüger

❮ Previous
Next ❯

Citations

Jul 3, 2020·British Journal of Biomedical Science·M A AliS E Ayoub
Jul 4, 2018·Frontiers in Oncology·Jens C Hahne, Nicola Valeri
Feb 23, 2020·Frontiers in Oncology·Águeda Martínez-BarriocanalHiginio Dopeso
Nov 30, 2019·Frontiers in Oncology·Ariadna BoloixMiguel F Segura
Jan 25, 2020·Molecular Cell·Christiane E OliveroNadya Dimitrova

❮ Previous
Next ❯

Methods Mentioned

BETA
RNA-Seq

Software Mentioned

Origin
DiSc
STATA
Engauge Digitizer
Meta
Review Manager

Related Concepts

Related Feeds

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.