LncRNA RP11-79H23.3 Functions as a Competing Endogenous RNA to Regulate PTEN Expression through Sponging hsa-miR-107 in the Development of Bladder Cancer

International Journal of Molecular Sciences
Hong ChiJunxia Chen

Abstract

Accumulating evidence indicates that the aberrant expression of long noncoding RNAs (lncRNAs) is involved in tumorigenesis and cancer development. However, the biological functions and underlying mechanisms of lncRNAs in bladder cancer (BC) remain largely unknown. Here, we analyzed the lncRNA and mRNA expression profiles in BC using a microarray assay. We found that lncRNA RP11-79H23.3 and phosphatase and tensin homolog (PTEN) were significantly downregulated in BC tissues and cells. Meanwhile, RP11-79H23.3 expression was negatively correlated with clinical stage in BC. Functionally, we found that overexpression of RP11-79H23.3 could suppress cell proliferation, migration, and cell cycle progression, rearrange the cytoskeleton, and induce apoptosis in vitro. Moreover, upregulation of RP11-79H23.3 inhibited the angiogenesis, tumorigenesis, and lung metastasis in vivo, whereas RP11-79H23.3 knockdown exerted a contrary role. Mechanistically, we identified that RP11-79H23.3 could directly bind to miR-107 and abolish the suppressive effect on target gene PTEN, which leads to inactivation of the PI3K/Akt signaling pathway. Taken together, we first demonstrated that RP11-79H23.3 might suppress the pathogenesis and development of BC by...Continue Reading

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Citations

Feb 29, 2020·International Journal of Molecular Sciences·Xing ChenNa-Na Guan
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Erin SellarsLeonardo Salmena
Jun 3, 2020·European Journal of Pharmacology·Milad AshrafizadehMasoud Najafi
Apr 3, 2021·Journal of Cellular and Molecular Medicine·Wen-Jie LuoYi-Ping Zhu

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Datasets Mentioned

BETA
GSE89006

Methods Mentioned

BETA
transfection
flow cytometry
xenograft
immunoprecipitation
pull down
RIP
anti-AGO2 RIP
PCR
transfections
electrophoresis

Software Mentioned

SPSS
TargetScan
GraphPad Prism
miRcode

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