LncRNA SNHG3/miRNA-151a-3p/RAB22A axis regulates invasion and migration of osteosarcoma

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Shengnai ZhengLei Yang

Abstract

To elucidate the potential function of lncRNA SNHG3 in the development of osteosarcoma. Quantitative real-time polymerase chain reaction was conducted for detection of SNHG3, miRNA-151a-3p and RAB22 A in osteosarcoma tissues and cells. Receiver operating characteristic curve was introduced to analyze the diagnostic potential of SNHG3 in osteosarcoma. Correlation between SNHG3 expression and the overall survival of osteosarcoma patients was evaluated using Kaplan-Meier method. Invasive and migratory potentials of osteosarcoma cells were examined by Transwell assay. Furthermore, dual-luciferase reporter gene assay, RNA-pull down and RIP assay were used to verify the binding of SNHG3/RAB22 A to miRNA-151a-3p. The function of SNHG3/miRNA-151a-3p/RAB22 A axis in osteosarcoma was finally confirmed by rescue experiments. SNHG3 and RAB22 A were highly expressed in osteosarcoma patients, while miRNA-151a-3p was lowly expressed. The overall survival of osteosarcoma patients with high expression of SNHG3 was shorter than those with low expression. SNHG3 overexpression markedly promoted invasive and migratory potentials of osteosarcoma cells. Through dual-luciferase reporter gene assay, both SNHG3 and RAB22 A could bind to miRNA-151a-3p. R...Continue Reading

References

Jun 22, 2005·Neoplasia : an International Journal for Oncology Research·Ichiro OkamotoHubert Pehamberger
Mar 31, 2009·International Journal of Cancer. Journal International Du Cancer·Lisa MirabelloSharon A Savage
Aug 2, 2011·Cell·Leonardo SalmenaPier Paolo Pandolfi
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
May 11, 2013·British Journal of Cancer·S W CheethamM E Dinger
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Qiang ZhangJie Yao
Sep 28, 2013·Cancer Discovery·Florian A Karreth, Pier Paolo Pandolfi
Jan 17, 2014·Nature·Yvonne TayPier Paolo Pandolfi
Nov 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yongqiang DongXuhui Zhou
Dec 24, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ruixi LiNatasha V Raikhel
Sep 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ting ZhangLi Liu
Nov 6, 2015·Nature Medicine·Maite Huarte
Aug 25, 2016·OncoTargets and Therapy·Wen-Kai XiaWei-Dong Mao

❮ Previous
Next ❯

Citations

May 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yun-Jiao TianDong-Ju Zhao
Apr 23, 2020·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Mar 4, 2020·International Journal of Molecular Medicine·Miao HeZhaoying Yang
Dec 10, 2020·Cancer Cell International·Bin XuJunfei Shao
Jan 8, 2021·International Journal of General Medicine·Lili WangYongning Sun
May 26, 2021·Technology in Cancer Research & Treatment·Yongqun LiJiguang Meng
Jun 22, 2021·The Kaohsiung Journal of Medical Sciences·Xu GuoHong-Yu Zhao
Jun 19, 2021·Frontiers in Cell and Developmental Biology·Hongyuan JinHangyu Li
Jul 27, 2021·Journal of Healthcare Engineering·Baojie KangYing Zhang
Jul 22, 2021·British Poultry Science·Xinchao ZhangGenxi Zhang
Jul 30, 2021·Journal of Orthopaedic Surgery and Research·Zhanhu MiPeng Ye
Apr 6, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dawei GeXiaojian Cao
Aug 24, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Liwei YuTong Xu
Aug 28, 2021·Biology·Jildou van der WerfNicholas Ian Fleming
Sep 12, 2021·Cell Biology and Toxicology·Yichi ZhouChengjun Sun
Sep 21, 2021·Molecular Biotechnology·Yongxiang LiuJinglong Yan
Oct 15, 2021·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Zeng-Peng SunWei-Min Yi
Jan 13, 2022·Molecular Therapy : the Journal of the American Society of Gene Therapy·Xingwen WangYing Hu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.