LncRNA SNHG5 promotes nasopharyngeal carcinoma progression by regulating miR-1179/HMGB3 axis

BMC Cancer
Dengtao LiuXiao Gu

Abstract

Long noncoding RNAs (lncRNAs) have been reported to be important regulators in pathogenesis of human cancers, including nasopharyngeal carcinoma (NPC). Here, we mainly aimed to explore the mechanisms of LncRNA-SNHG5/ miR-1179/HMGB3 axis in NPC progression. RT-qPCR and Western blot analysis were employed to detect mRNA and protein expressions. CCK-8, Transwell and dual luciferase reporter assays were applied to investigate functions of LncRNA-SNHG5/miR-1179/HMGB3 axis. Upregulation of lncRNA-SNHG5 and downregulation of miR-1179 were identified in NPC, which were associated with adverse clinical outcomes. Functionally, upregulation of lncRNA-SNHG5 and downregulation of miR-1179 accelerated NPC cell proliferation, migration and invasion. Furthermore, lncRNA-SNHG5 acted as a molecular sponge of miR-1179 in NPC. Besides that, upregulation of HMGB3 was found in NPC, and knockdown of HMGB3 restrained NPC progression. Moreover, HMGB3, a target of miR-1179, regulated NPC progression by mediating LncRNA-SNHG5/miR-1179 axis. LncRNA SNHG5 serves as a tumor promoter in NPC by sponging miR-1179 and upregulating HMGB3.

References

Jun 27, 2014·Seminars in Cell & Developmental Biology·Je-Hyun YoonMyriam Gorospe
Sep 10, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeff P BruceFei-Fei Liu
Oct 25, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Shengnan GuoZhitu Zhu
Nov 11, 2017·Chinese Journal of Cancer·Kuang-Rong WeiWan-Qing Chen
Sep 27, 2018·Cancer Cell International·Cheng JuXiao-Bin Lv

❮ Previous
Next ❯

Citations

Aug 6, 2020·OncoTargets and Therapy·Wei HanWei Guan
Sep 20, 2020·Journal of Personalized Medicine·Izabela ŁasińskaJacek Mackiewicz
Aug 23, 2020·Diagnostics·Engku Nur Syafirah E A RChan Yean Yean
Jan 12, 2021·Molecular and Cellular Biochemistry·Bin WenKui Zhao
Jan 9, 2021·Briefings in Bioinformatics·Qing-Wen WuChun-Hou Zheng
Mar 22, 2021·Bioorganic & Medicinal Chemistry Letters·Xiaodong YinWenbin Wang

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical
chemical treatment
PCR
transfection

Software Mentioned

TargetScan
SPSS
Graphpad Prism

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Actin, Myosin & Cell Movement

Contractile forces generated by the actin-myosin cytoskeleton are critical for morphogenesis, but the cellular and molecular mechanisms of contraction have been elusive for many cell shape changes and movements. Here is the latest research on the roles of actin and myosin in cell movement.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

© 2021 Meta ULC. All rights reserved