Abstract
Long non-coding RNAs small nucleolar RNA host gene 5 (lncRNA SNHG5) plays well-defined roles in the malignant progression. However, the roles of SNHG5 in chronic obstructive pulmonary disease (COPD) progression remain unclear. In the present study, SNHG5 expression was low expressed in COPD tissues and positively correlated with low forced expiratory volume in one second (FEV1)% in patients. Subsequently, cigarette smoke extract (CSE) decreased SNHG5 expression in 16HBE cells, and SNHG5 overexpression in 16HBE cells mitigated the effects of CSE on the proliferation, apoptosis and inflammation (IL-1β, IL-6 and TNF-a). Mechanistically, SNHG5 functioned as a competing endogenous RNA (ceRNA) for miR-132 in COPD, thereby increasing the expression of the miR-132 target PTEN. Moreover, rescue assays demonstrated that PTEN suppression (or miR-132 overexpression) attenuated the effects of SNHG5 upregulation on COPD progression. In conclusion, the SNHG5-miR-132-PTEN axis might play critical roles in COPD development, providing an effective target for the treatment of COPD.
Citations
Aug 15, 2020·Frontiers in Genetics·Manuel Flores-Concha, Ángel A Oñate
Nov 11, 2020·Molecular and Cellular Biochemistry·Jiao WangLihai Zhang
Jan 14, 2021·Neurological Research·Qilong DengLizhong Ma
Jan 23, 2021·Journal of Biochemistry·Min WangPeng Zhang
Feb 7, 2021·Respiratory Research·Qing SongXiang-Ming Liu
Dec 15, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Yuanyuan WangNianzhi Zhang
Mar 19, 2021·Biotechnology and Applied Biochemistry·Chenying ZhangXiuwen Kang
Apr 25, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xin YuanMiaomiao Xue
May 9, 2021·Life Sciences·Lin SongXuejun Guo
May 28, 2021·Frontiers in Pharmacology·Huangdong DaiLiang Zhao
Jun 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Liu Kai-XinXu Peng
Aug 6, 2021·Frontiers in Genetics·Xue-Min ShiSu-Hua Wang
Jul 11, 2021·BMC Pulmonary Medicine·Panfeng ChenXiumei Guo
Aug 3, 2021·Bioengineered·Hui LiYaozhou Tian
Sep 16, 2021·Cell Biology and Toxicology·Jing ZhaoQizhan Liu
Nov 13, 2021·DNA and Cell Biology·Li ZhangJinming Liu