LncRNA SOX21-AS1 is associated with progression of hepatocellular carcinoma and predicts prognosis through epigenetically silencing p21

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Congxin WeiRunde Jiang

Abstract

Long non-coding RNAs (lncRNAs) have been widely reported in various cancers due to their special molecular mechanisms. LncRNA SOX21-AS1 has been discovered to be a tumor facilitator in several types of human cancers. However, the expression pattern, clinical value and biological effects in hepatocellular carcinoma (HCC) are still unknown. In this study, we detected the high expression level of SOX21-AS1 in tumor tissues and cell lines through performing qRT-PCR analysis. The prognostic value of SOX21-AS1 was identified. Moreover, the biological effects of SOX21-AS1 on HCC cell activities were evaluated by functional assays, such as MTT, colony formation assay and transwell assay. As a result, silenced SOX21-AS1 suppressed cell proliferation and metastasis, resulted in cell cycle arrest, and induced apoptosis in hepatocellular carcinoma. Mechanically, RIP was conducted to prove that SOX21-AS1 could bind with EZH2. ChIp assay was carried out and manifested that SOX21-AS1 epigenetically silenced p21 via recruiting EZH2 to the promoter of p21. Finally, rescue assays were designed and carefully conducted to investigate whether SOX21-AS1 can interact with p21 to affect hepatocellular carcinoma progression. Generally, our results sugg...Continue Reading

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Citations

Jan 19, 2019·Cell Cycle·Shuman HuangYulin Zhao
Mar 27, 2019·Journal of Cellular Physiology·Xiaoyan ZhangZhenyu Zhang
Aug 28, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Sen HanZhihong Yang
May 18, 2019·Journal of Experimental & Clinical Cancer Research : CR·Haoming MaiDeke Jiang
Mar 27, 2020·Frontiers in Oncology·Junlong SunJinlong Shi
Jan 24, 2020·NPJ Genomic Medicine·Gabriela D A GuardiaPedro A F Galante
Jun 5, 2020·Cancer Management and Research·Ning ZhouLibo Man
Jan 16, 2021·NPJ Genomic Medicine·Gabriela D A GuardiaPedro A F Galante
Aug 16, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Ganesh Kumar BarikBhargab Kalita
Sep 1, 2021·Cancer Cell International·Biao LiuJianye Liu

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