LncRNA TINCR is associated with clinical progression and serves as tumor suppressive role in prostate cancer

Cancer Management and Research
Liming DongYili Liu

Abstract

Terminal differentiation-induced non-coding RNA (TINCR) has been suggested to have aberrant expression in multiple human cancers, and functions as tumor suppressor or promoter in various types of human tumors depending on the specific cancer types. The expression status and biological function of TINCR in prostate cancer is still unknown. In our study, we detected TINCR expression in prostate cancer tissue samples and cell lines, and analyzed the association between TINCR expression and clinical parameters in 160 prostate cancer patients. Moreover, we conducted gain-of-function and loss-of-function studies in prostate cancer cell to explore the biological function and molecular mechanism of TINCR. In our results, low-expression TINCR was observed in prostate cancer, and correlated with advanced clinical T stage, lymph node involvement, distant metastasis, high Gleason score and poor prognosis in prostate cancer patients. Moreover, levels of TINCR expression were negatively associated with TRIP13 mRNA and protein expressions in prostate cancer tissues, and negatively regulated the TRIP13 mRNA and protein expressions in prostate cancer cell lines. TINCR inhibits prostate cancer cell proliferation, migration and invasion via suppr...Continue Reading

Citations

Jun 5, 2019·Nucleic Acids Research·Marta AdinolfiManuela Helmer-Citterich
Jan 31, 2019·Diagnostics·Jochen Neuhaus, Bo Yang
Oct 22, 2020·Technology in Cancer Research & Treatment·Xiaojie WangXiaoqin Deng
Dec 15, 2020·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ke LuYongchang Chen
Aug 27, 2019·Pathology, Research and Practice·Sixuan LiZhihua Yin
Feb 27, 2021·Frontiers in Cell and Developmental Biology·Yuanshen MaoZhong Wang

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Methods Mentioned

BETA
RNA-seq

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Quantity One

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