LncRNA TP73-AS1 Promotes Cell Proliferation and Inhibits Cell Apoptosis in Clear Cell Renal Cell Carcinoma Through Repressing KISS1 Expression and Inactivation of PI3K/Akt/mTOR Signaling Pathway

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Guanghua LiuZhigang Ji

Abstract

Emerging evidence suggests that long non-coding RNAs (lncRNAs) play a vital regulatory role in the pathogenesis and progression of renal cell carcinoma (RCC). We aim to determine lncRNA profiles in clear cell RCC (ccRCC) and investigate key lncRNAs involved in ccRCC tumorigenesis and progression. RNA sequencing technique and qPCR were used to determine the candidate lncRNAs in ccRCC tissues. The correlations between lncRNA P73 antisense RNA 1T (TP73-AS1) levels and survival outcomes were analyzed to elucidate its clinical significance. The underlying mechanisms of TP73-AS1 in ccRCC were analyzed through in vitro functional assays. We found TP73-AS1 was upregulated in 40 ccRCC tissues compared with adjacent normal renal tissues and increased TP73-AS1 was correlated to aggressive clinicopathologic features and unfavorable prognosis. Knockdown of TP73-AS1 suppressed cell proliferation, invasion and induced cell apoptosis. We also identified KISS-1 metastasis-suppressor (KISS1) was significantly upregulated in TP73-AS1 knockdown cells. Further, we revealed that TP73-AS1 suppressed KISS1 expression through the interaction with Enhancer of zeste homolog 2 (EZH2) and the specific binding to KISS1 gene promoter region. Knockdown of KIS...Continue Reading

Citations

Mar 20, 2019·Journal of Cellular Physiology·Jinglin LiYunfu Cui
Sep 25, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Wangwang ChenZekuan Xu
Mar 11, 2020·Cancer Metastasis Reviews·Thuc LyDanny R Welch
Feb 24, 2020·Clinical & Experimental Metastasis·Sitaram HariharDanny R Welch
Sep 16, 2020·Journal of Experimental & Clinical Cancer Research : CR·Shanshan ZhaoSong Zhang
Apr 26, 2020·Molecular Biology Reports·Ningni JiangJuan Peng
Oct 28, 2019·Bioscience Reports·Caizhi ChenWen Zou
Oct 2, 2020·Molecular Medicine Reports·Dong TangBaohui Liu
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Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri

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