LncRNA TUG1 interacting with miR-144 contributes to proliferation, migration and tumorigenesis through activating the JAK2/STAT3 pathway in hepatocellular carcinoma

The International Journal of Biochemistry & Cell Biology
Jun LvZujiang Yu

Abstract

Recently, it is reported that taurine upregulated gene 1 (TUG1) participates in the tumor progression by acting as a competing endogenous RNA (ceRNA) of miRNAs. Nonetheless, whether TUG1 could serve as a ceRNA of miR-144 in hepatocellular carcinoma (HCC) progression remains undefined. Here, our results indicated that there was a marked rise in TUG1 expression in HCC tissues and cells, and downregulation of TUG1 hindered proliferation and migration of HCC cells. Additionally, TUG1 was validated to act as a molecular sponge of miR-144. Furthermore, we found that TUG1 interacting with miR-144 contributed to proliferation and migration of HCC cells via activating the JAK2/STAT3 pathway in vitro. Moreover, TUG1 knockdown inhibited HCC tumor growth in vivo through upregulating miR-144 via inactivation of the JAK2/STAT3 pathway. In conclusion, TUG1 interacting with miR-144 contributed to proliferation, migration and tumorigenesis through activation of the JAK2/STAT3 pathway in HCC.

Citations

Oct 20, 2018·Molecular Carcinogenesis·Jianwei LinLinwei Wu
Dec 24, 2018·Clinical and Experimental Pharmacology & Physiology·Yang YuHongbo Guan
Apr 19, 2019·The International Journal of Neuroscience·Chunni CaoQi Chen
Oct 28, 2019·Bioscience Reports·Menglin Cong, Rui Jing
Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hanyu ShiHaiqing Gao
Jun 27, 2020·Cancer Biotherapy & Radiopharmaceuticals·Wei LiTao He
Oct 3, 2018·Journal of Cellular and Molecular Medicine·Hongjiang LiuBaohua Jiao
Apr 12, 2020·International Journal of Molecular Sciences·Omid KooshkakiBehzad Baradaran
Aug 17, 2020·Archives of Physiology and Biochemistry·Dan LiuBokui Xiao
Dec 28, 2018·Acta Biochimica Et Biophysica Sinica·Hui ZhouFusheng Wan
Feb 6, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shun ZhangWujun Chen
Oct 17, 2020·Cancer Cell International·Gang XuZhong-Tao Zhang
Apr 8, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Ri ChenHeng Zhang
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
May 28, 2021·Molecular Medicine·Miao DaShuwen Han
Jun 2, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Chakrabhavi Dhananjaya MohanKanchugarakoppal S Rangappa
Oct 21, 2020·Biomedical Journal·Po-Shuan HuangKwang-Huei Lin
Jul 13, 2021·Frontiers in Oncology·Xinrong LinRui Wang
Jul 30, 2021·Seminars in Cancer Biology·Ganji Purnachandra NagarajuBassel F El-Rayes
Oct 6, 2021·International Journal of Immunopathology and Pharmacology·Ke LiLi Zhuang

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