LncRNA WDFY3-AS2 suppresses proliferation and invasion in oesophageal squamous cell carcinoma by regulating miR-2355-5p/SOCS2 axis.

Journal of Cellular and Molecular Medicine
Qing ZhangHongtao Liu

Abstract

Long non-coding RNAs (lncRNAs) widely participate in ESCC development and progression; however, the prognostic factors and therapeutic strategies implicated in ESCC development and progression remain to be under investigation. The purpose of the current study was to explore whether WDFY3-AS2 may be a potential prognostic factor and investigate its biological functions in ESCC. Here, WDFY3-AS2 was frequently down-regulated in ESCC tissues and cells, and its expression was correlated with TNM stage, lymph node metastasis and poor prognosis of ESCC patients. Moreover, WDFY3-AS2 down-regulation significantly promoted cell proliferation and invasion, whereas WDFY3-AS2 up-regulation markedly suppressed cell proliferation and invasion in ESCC EC9706 and TE1 cells, coupled with EMT phenotype alterations. WDFY3-AS2 functioned as a competing endogenous RNA (ceRNA) for sponging miR-2355-5p, further resulted in the up-regulation of its target gene SOCS2, followed by suppression of JAK2/Stat5 signalling pathway, to suppress ESCC cell proliferation and invasion in EC9706 and TE1 cells. These findings suggest that WDFY3-AS2 may participate in ESCC development and progression, and may be a novel prognostic factor for ESCC patients, and thus ta...Continue Reading

References

Sep 29, 2005·Journal of Clinical Pathology·F FarabegoliM Taffurelli
Jul 27, 2007·BMC Cancer·Michael C HaffnerWolfgang Doppler
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 21, 2011·The Lancet Oncology·Katrin M SjoquistUNKNOWN Australasian Gastro-Intestinal Trials Group
Jan 15, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Vera OppedijkMaarten C C M Hulshof
Jul 13, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Khashayar FakhrianHans Geinitz
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Dec 17, 2015·Nature Reviews. Genetics·Jeffrey J Quinn, Howard Y Chang
Nov 19, 2019·Journal of Cellular and Molecular Medicine·Xinyue SongMinjie Wei
Nov 22, 2019·Journal of Experimental & Clinical Cancer Research : CR·Shan LeiJianxin Jiang

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE11011
KYSE150
KYSE180

Methods Mentioned

BETA
transfection
PCR
Assay
immunoprecipitation
RIP

Software Mentioned

lncATLAS
GraphPad Prism
DIANA Tools
lncATLAS prediction
ENCORI Pan ‐ Cancer Analysis Platform
StarBase
TargetScan
GraphPad

Related Concepts