LncRNA & Wnt signaling in colorectal cancer.

Cancer Cell International
Zeeshan JavedWilliam C Cho

Abstract

The outlook for new therapeutic approaches is pivotal to ameliorate the deterioration caused by the abrogated Wnt signaling. Long non-coding RNAs (lncRNAs) are tiny molecules that have begun emerging as vital molecular manager for the regulation of various cellular processes at transcription and translation levels in the colorectal cancer (CRC). Targeting Wnt pathway with lncRNA seems a promising approach to eradicate CRC. However, little is known of their active role in commencing both apoptosis and proliferation in CRC. This article  reviews the importance of these molecules in the pathogenesis of CRC and also emphasizes on the development of new therapeutic strategies to cope with the Wnt mediated CRC.

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Citations

Apr 3, 2021·Cancer Cell International·Zeeshan JavedJavad Sharifi-Rad
Apr 27, 2021·Pharmacology & Therapeutics·Li ChenHaibo Xu

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Methods Mentioned

BETA
ubiquitination
xenograft
Chip-Seq
RNA-seq
RIP
methylation profiling
single-cell sequencing

Related Concepts

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

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