LncRNA XIST promotes human lung adenocarcinoma cells to cisplatin resistance via let-7i/BAG-1 axis

Cell Cycle
Jing SunYue Wang

Abstract

Long noncoding RNAs (lncRNAs) have been identified as oncogenes or tumor suppressors that are involved in tumorigenesis and chemoresistance. LncRNA XIST expression is upregulated in several cancers, however, its biologic role in the development of the chemotherapy of human lung adenocarcinoma (LAD) has not been elucidated. This study aimed to observe the expression of LncRNA XIST in LAD and to evaluate its biologic role and clinical significance in the resistance of LAD cells to cisplatin. LncRNA XIST expression was markedly increased in cisplatin-resistant A549/DDP cells compared with parental A549 cells as shown by qRT-PCR. LncRNA XIST overexpression in A549 cells increased their chemosensitivity to cisplatin both in vitro and in vivo by protecting cells from apoptosis and promoting cell proliferation. By contrast, LncRNA XIST knockdown in A549/DDP cells decreased the chemoresistance. We revealed that XIST functioned as competing endogenous RNA to repress let-7i, which controlled its down-stream target BAG-1. We proposed that XIST was responsible for cisplatin resistance of LAD cells and XIST exerted its function through the let-7i/BAG-1 axis. Our findings suggested that lncRNA XIST may be a new marker of poor response to cis...Continue Reading

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Citations

Jul 5, 2018·Journal of Cellular and Molecular Medicine·Ruoming WangJingjing Seng
Jan 7, 2020·The Journal of Gene Medicine·Pengfei SunYuhua Jia
Jun 26, 2020·Clinical Genetics·He-da ZhangJin-Hai Tang
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Apr 7, 2021·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Sai LiDatong Sun
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Jun 29, 2021·Frontiers in Cell and Developmental Biology·Wenlun WangLingyun Zhu

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Methods Mentioned

BETA
Flow cytometry
xenograft
xenografts
co-immunoprecipitation
immunoprecipitation
pull down
PCR
transfection
electrophoresis

Software Mentioned

XIST
CellQuest

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