lncRNAs as potential molecular biomarkers for the clinicopathology and prognosis of glioma: A systematic review and meta-analysis

Gene
Qian ZhouWeiping Li

Abstract

An increasing number of studies have shown that long noncoding RNAs (lncRNAs) play important roles in the development of glioma. However, a systematic review and meta-analysis to evaluate the clinical value of lncRNA expression in glioma patients is lacking. We performed this study to assess the relationship between the expression of various lncRNAs and the clinicopathological features, diagnosis and prognosis of glioma. Eligible studies were identified through a comprehensive literature search. We conducted a subgroup analysis to assess the clinicopathological value of urothelial carcinoma associated 1 (UCA1). Pooled hazard ratios (HRs) of lncRNAs for survival were calculated to analyze the prognostic performance of lncRNAs. In total, 40 studies, including 30 investigating clinicopathological features, 3 investigating diagnoses and 32 investigating prognoses, were analyzed in this study. UCA1 expression was positively associated with tumor size (odds ratio [OR], 2.09; 95% confidence interval [CI], 1.06-4.15; P < 0.001) and World Health Organization (WHO) grade (OR, 3.84, [95% CI 1.84-8.01], P < 0.001). In the prognostic meta-analysis, high metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) expression could predict...Continue Reading

Citations

Aug 18, 2018·Journal of Cellular and Molecular Medicine·Sevinci PopCristiana Tanase
Mar 3, 2019·Journal of Cellular Biochemistry·Li FengYonggang Zhu
Aug 23, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Hanyu ShiHaiqing Gao
Jun 14, 2020·BMC Cancer·Zehao CaiWenbin Li
Jun 14, 2019·Frontiers in Genetics·Le Ou-YangZexuan Zhu
Feb 13, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xiaozhi LiYunhui Liu
Jul 29, 2021·NAR Cancer·Keisuke KatsushimaRanjan J Perera
Oct 26, 2021·Journal of the Egyptian National Cancer Institute·Abdol Ali EbrahimiShaghayegh Kamian
Oct 29, 2021·Acta Naturae·T F KovalenkoM S Pavlyukov

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