LncRNAs join hands together to regulate neuroblastoma progression

Molecular & Cellular Oncology
Tanmoy Mondal, Chandrasekhar Kanduri

Abstract

Trait associated single nucleotide polymorphisms often overlap with noncoding transcripts but their contribution to disease phenotype is poorly investigated. Our study on neuroblastoma risk associated 6p22.3 locus derived long noncoding RNAs (lncRNAs) demonstrates that functional co-operation between sense-antisense CASC15 and NBAT1 lncRNAs control neuroblastoma progression via regulating SOX9-CHD7-USP36 regulatory axis.

References

May 9, 2008·The New England Journal of Medicine·John M MarisHakon Hakonarson
Jun 24, 2015·Cancer Research·Mike R RussellKristina A Cole
Nov 11, 2016·Nature Reviews. Disease Primers·Katherine K MatthayWilliam A Weiss
Mar 2, 2018·Nature Communications·Mohamad Moustafa AliChandrasekhar Kanduri

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Methods Mentioned

BETA
xenograft
ubiquitination

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