PMID: 808145Jul 1, 1975

Loa loa: experimental infection in two species of African primates

The American Journal of Tropical Medicine and Hygiene
T C Orihel, P J Moore

Abstract

Four species of primates, baboon (Papio anubis), patas monkeys (Erythrocebus patas), green monkey (Cercopithecus aethiops) and chimpanzee (Pan troglodytes) were inoculated with third-stage larvae of a human strain of Loa loa from Cameroon, West African. The baboon and patas monkeys developed patent infections after 135 to 148 days; the green monkeys and chimpanzee did not. In each animal which became patent, microfilaremia rose rapidly to high levels. In the baboon, but not in the patas monkeys, there was a suppression of microfilaremia during the 4th month of patency. After splenectomy, microfilariae reappeared in the peripheral blood in large numbers. In both baboon and patas monkeys, the microfilariae of Loa loa maintain the diurnal periodicity so characteristic of their behavior in man.

Citations

Jan 1, 1982·Transactions of the Royal Society of Tropical Medicine and Hygiene·Charles D MackenzieD A Denham
Mar 31, 2019·Nature Communications·Nicolas P PionnierJoseph D Turner
May 5, 2011·The American Journal of Tropical Medicine and Hygiene·Federico GobbiZeno Bisoffi
Aug 1, 1990·Annals of Tropical Medicine and Parasitology·B O Duke
Jan 18, 2007·Annals of Tropical Medicine and Parasitology·M Boussinesq

Related Concepts

Anthropoidea
Autopsy
Blood
Cercopithecus
Pan troglodytes
Circadian Rhythms
Erythrocebus patas
Filariasis
Loiasis
Microfilaria

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