Load dependence of cardiac output in biventricular pacing: left ventricular volume overload in pigs

The Journal of Thoracic and Cardiovascular Surgery
George BerberianH M Spotnitz

Abstract

Previous work from our laboratory has demonstrated that optimization of biventricular pacing is load dependent. Cardiac output was maximized with a ventricular-ventricular delay of +40 milliseconds (right ventricle-first pacing) during right ventricular pressure overload and with a ventricular-ventricular delay of -40 milliseconds (left ventricle-first pacing) during right ventricular volume overload. We hypothesized that a model of left ventricular volume overload would also have specific timing requirements during biventricular pacing for optimization of cardiac output. After median sternotomy in 6 anesthetized pigs, complete heart block was induced by ethanol ablation. A conduit was grafted from the left ventricle to the left atrium to produce left ventricular volume overload. An ultrasonic flow probe was placed around the conduit to measure retrograde flow that averaged 50% of cardiac output. During epicardial atrial tracking DDD biventricular pacing, atrioventricular delay was varied between 60 and 270 milliseconds in 30-millisescond increments for 20-second intervals. After determination of optimum atrioventricular delay, ventricular-ventricular delay was varied in 20-millisecond increments from +80 to -80 milliseconds fo...Continue Reading

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Jun 3, 2004·The Journal of Thoracic and Cardiovascular Surgery·David G RabkinHenry M Spotnitz
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Citations

Oct 27, 2009·American Journal of Physiology. Heart and Circulatory Physiology·T Alexander QuinnHenry M Spotnitz
Jul 20, 2010·Journal of Cardiothoracic and Vascular Anesthesia·Mathew E SpotnitzHenry M Spotnitz
Aug 29, 2007·The Journal of Thoracic and Cardiovascular Surgery·George BerberianHenry M Spotnitz
May 23, 2015·Journal of Cardiothoracic and Vascular Anesthesia·Robin M BrusenHenry M Spotnitz
Jun 6, 2006·American Journal of Physiology. Heart and Circulatory Physiology·T Alexander QuinnHenry M Spotnitz
Mar 26, 2013·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Alice WangHenry M Spotnitz

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