Load-induced changes in the diffusion tensor of ovine anulus fibrosus: A pilot MRI study

Journal of Magnetic Resonance Imaging : JMRI
Monique C TourellJ Paige Little

Abstract

To assess the feasibility of diffusion tensor imaging (DTI) for evaluating changes in anulus fibrosus (AF) microstructure following uniaxial compression. Six axially aligned samples of AF were obtained from a merino sheep disc; two each from the anterior, lateral, and posterior regions. The samples were mechanically loaded in axial compression during five cycles at a rate and maximum compressive strain that reflected physiological conditions. DTI was conducted at 7T for each sample before and after mechanical testing. The mechanical response of all samples in unconfined compression was nonlinear. A stiffer response during the first loading cycle, compared to the remaining cycles, was observed. Change in diffusion parameters appeared to be region-dependent. The mean fractional anisotropy increased following mechanical testing. This was smallest in the lateral (2% and 9%) and largest in the anterior and posterior samples (17-25%). The mean average diffusivity remained relatively constant (<2%) after mechanical testing in the lateral and posterior samples, but increased (by 5%) in the anterior samples. The mean angle made by the principal eigenvector with the spine axis in the lateral samples was 73° and remained relatively consta...Continue Reading

References

Jan 1, 1989·Connective Tissue Research·J J CassidyE Baer
Apr 1, 1983·Engineering in Medicine·J A Klein, D W Hukins
Apr 3, 1981·Biochimica Et Biophysica Acta·G LyonsM B Sweet
May 20, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·E W Hsu, L A Setton
Nov 24, 1999·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·J C IatridisV C Mow
Aug 10, 2000·Magnetic Resonance Imaging·S SkareM Ingvar
Nov 15, 2000·Journal of Shoulder and Elbow Surgery·R G PollockV C Mow
May 30, 2002·Clinical Biomechanics·J E ReidD W L Hukins
Jun 24, 2004·Journal of Biomechanics·J C James C Iatridis, Iolo ap Gwynn
Sep 28, 2004·Physics in Medicine and Biology·Simon C DrewMark J Pearcy
Jan 18, 2005·Journal of Biomechanics·James C IatridisDavid A Ryan
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Gary D Fullerton, Andrés Rahal
Mar 27, 2007·Journal of Biomechanics·J P LittleM J Pearcy
Oct 2, 2007·The Journal of Bone and Joint Surgery. British Volume·M A Edgar
Oct 11, 2008·Journal of Applied Physiology·Kyle P Quinn, Beth A Winkelstein
Feb 5, 2010·Journal of the Mechanical Behavior of Biomedical Materials·J P LittleC J Adam
Oct 13, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·ShaoKuan ZhengFarid Badar
Dec 3, 2010·Disease Models & Mechanisms·Lachlan J SmithDawn M Elliott
Feb 22, 2011·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Grace D O'ConnellDawn M Elliott
Sep 29, 2011·The Orthopedic Clinics of North America·Sharmila MajumdarJohn Kurhanewicz
May 8, 2013·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Deva D Chan, Corey P Neu
Apr 2, 2014·Journal of Biomedical Optics·Paulo RorizJosé António de Oliveira Simões
Jan 13, 2016·Magma·Alexander C WrightDawn M Elliott

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Citations

Aug 15, 2019·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Li LiKejia Cai
May 31, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Uran FeriziJosé G Raya
Aug 28, 2021·Journal of Mammary Gland Biology and Neoplasia·Gina ReyeHonor J Hugo

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