Abstract
Stimulation of the angiotensin II type 1 (AT1) receptor by angiotensin II appears to be mandatory for the acute load-induced hypertrophic response of cultured neonatal rat cardiocytes, but its role in the adult heart is controversial. We tested the hypothesis that AT1 receptor blockade will inhibit the acute induction of proto-oncogenes and protein synthesis by the elevation of systolic wall stress in isolated beating adult rat hearts. Using the established isovolumic perfused heart preparation under constant coronary flow, we found that an increment in left ventricular balloon volume generated an increase in systolic wall stress. The induction of left ventricular c-fos and c-myc mRNA (Northern blotting) was assessed in hearts subjected to increased systolic load without AT1 blockade (No AT1, n = 11) and with AT1 blockade (AT1, n = 11, losartan 40 mg.kg-1.d-1 x 5 days followed by 10(-5) mol/L infusion during perfusion). Flaccid hearts (no left ventricular balloon) served as controls (C, n = 9). The stimulation of new protein synthesis in response to increased systolic load was measured by incorporation of [3H]phenylalanine into cardiac proteins. Elevation of systolic load was associated with a twofold (P < .05) increase in c-fo...Continue Reading
References
Jul 1, 1975·The Journal of Clinical Investigation·W GrossmanL P McLaurin
Mar 1, 1992·The Journal of Clinical Investigation·T TakahashiS Izumo
Feb 1, 1992·The Biochemical Journal·E A WoodcockI J Kuraja
Dec 1, 1991·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·K R ChienS Chien
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·H SchunkertB H Lorell
May 1, 1991·Journal of Molecular and Cellular Cardiology·I Sen, A K Rajasekaran
Dec 1, 1990·The Journal of Clinical Investigation·H SchunkertB H Lorell
Jan 11, 1990·The New England Journal of Medicine·A M Katz
Jul 1, 1988·The American Journal of Cardiology·E P Kromer, G A Riegger
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S IzumoV Mahdavi
Mar 11, 1985·Nucleic Acids Research·P FortJ M Blanchard
Feb 1, 1988·Journal of Molecular and Cellular Cardiology·C BautersB Swynghedauw
Nov 1, 1986·Molecular and Cellular Biology·M D SchneiderR Roberts
Apr 1, 1984·The American Journal of Cardiology·Y NakashimaR C Tarazi
Oct 1, 1980·The American Journal of Medicine·W Grossman
Mar 1, 1984·The American Journal of Physiology·Y KiraH E Morgan
Sep 1, 1980·The American Journal of Physiology·I H WilliamsH E Morgan
Nov 7, 1995·Proceedings of the National Academy of Sciences of the United States of America·M NakajimaV J Dzau
Feb 1, 1995·The Journal of Clinical Investigation·M StollT Unger
Aug 1, 1994·The American Journal of Physiology·J J LopezS S Tang
Dec 3, 1993·Cell·J SadoshimaS Izumo
Jan 9, 1996·Proceedings of the National Academy of Sciences of the United States of America·T YamadaV J Dzau
Dec 1, 1995·The Journal of Clinical Investigation·H SchunkertB H Lorell
Mar 18, 1997·Circulation·M KoideB A Carabello
Citations
Sep 12, 2000·Current Hypertension Reports·L P AudolyT M Coffman
Apr 6, 2000·The American Journal of Cardiology·B H Lorell
Jan 12, 2001·Journal of the American College of Cardiology·Y SakataM Hori
Dec 7, 2010·Cardiovascular Research·Suresh K VermaDavid E Dostal
Oct 6, 2001·Journal of Cardiovascular Pharmacology·M ShimoyamaC Shigemasa
Mar 11, 2003·The Journal of Physiology·N C SundgrenK L Thornburg
Jul 11, 2001·Biochemical and Biophysical Research Communications·A Yasaka, W Hayashida
Nov 15, 2002·Journal of Molecular and Cellular Cardiology·Pietro Amedeo ModestiGian Gastone Neri Serneri
Sep 1, 2000·Journal of Molecular and Cellular Cardiology·P OliviéroB Ostadal
Jul 16, 2008·Pharmacology & Therapeutics·K-D Schlüter, S Wenzel
Dec 1, 2005·Experimental Physiology·Todd A McBride
Dec 4, 2012·Acta Physiologica·J AroJ Rysä
Dec 26, 2006·Biochimica Et Biophysica Acta·Jarkko PiuholaHeikki Ruskoaho
Mar 31, 2004·The Journal of Biological Chemistry·Olli TenhunenHeikki Ruskoaho
Oct 19, 2001·Journal of Human Hypertension·H C Routledge, J N Townend
Mar 20, 1999·The Journal of Biological Chemistry·C Montessuit, A Thorburn
Jun 13, 1998·The Journal of Biological Chemistry·K YamamotoR T Lee
Jul 27, 1999·The Journal of Biological Chemistry·K YamamotoR T Lee
May 12, 1998·The American Journal of Physiology·J J MercadierM Aubier
Feb 10, 1999·The American Journal of Physiology·M KoideM R Zile
Jul 17, 1999·The American Journal of Physiology·K OginoD Burkhoff
Apr 8, 1998·The American Journal of Physiology·M HamawakiB A Carabello