Loading-induced changes on topographical distributions of the zonal properties of osteoarthritic tibial cartilage - A study by magnetic resonance imaging at microscopic resolution

Journal of Biomechanics
Jihyun LeeYang Xia

Abstract

The topographical distributions of the zonal properties of articular cartilage over the medial tibia from an experimental osteoarthritis (OA) model were evaluated as a function of external loading by microscopic Magnetic Resonance Imaging (µMRI). T2 relaxation times and cartilage thicknesses were measured at 17.6µm resolution from 118 specimens, which came from thirteen dogs (six 8-week and seven 12-week after surgery), with and without mechanical loading. In addition, bulk mechanical modulus was measured topographically from each tibia surface. The total thickness decreased significantly under the external loading, in which the relative thickness of the superficial zone (SZ) and the transitional zone (TZ) increased whereas the radial zones (RZs) decreased. In the bulk data, T2(55°) decreased significantly (p<0.001) at all OA-time-points, but T2(0°) decreased without significance (p>0.05) at 8-week. Complex relationships were found in the zonal tissue properties as a function of external loading with the progress of OA. T2 in the superficial zone changed more profoundly than the same properties in the radial zone as a function of external loading at all OA time-points. This study confirms that OA affects the load-induced change...Continue Reading

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Citations

Oct 31, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Nian WangYang Xia

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