Lobectomy Versus Sublobectomy in Metachronous Second Primary Lung Cancer: A Propensity Score Study

The Annals of Thoracic Surgery
Xiaodong YangQun Wang

Abstract

The optimal surgical approach for metachronous second primary lung cancer (MSPLC) has not been well established yet. In this study, survival outcome of lobectomy was compared with sublobectomy for MSPLC. A retrospective study was conducted based on the Surveillance, Epidemiology, and End Results database. Propensity score matching was used to reduce the potential bias caused by the variance of the clinicopathologic features of the first and second lung cancer. The effect of lobectomy and sublobectomy for MSPLC was assessed and explored in subgroup analyses. We identified 1,392 MSPLC patients, and 454 pairs of patients were matched. Lobectomy was associated with a significantly better survival (p = 0.023). Subgroup analyses showed that lobectomy achieved a significantly better prognosis if previous lung cancer was stage I, whereas sublobectomy had advantages in patients with initial stage III cancer. Moreover, patients with lobectomy had a significantly better prognosis in N0 disease but not in N1 or N2. Stratified by tumor size, the prognosis of sublobectomy was comparable to lobectomy for tumors sized 1 cm or smaller. Lobectomy was associated with a better survival in tumors sized 1 to 2 cm, although without statistical signif...Continue Reading

Citations

Jul 8, 2020·Journal of Cancer Research and Clinical Oncology·Kai-Hsiung KoTsai-Wang Huang
Feb 22, 2021·Interactive Cardiovascular and Thoracic Surgery·Seijiro SatoMasanori Tsuchida
Mar 19, 2021·Journal of Cardiothoracic Surgery·Yong YangLiang Duan
May 23, 2020·The Thoracic and Cardiovascular Surgeon·Alex FourdrainPascal Berna
Aug 30, 2020·The Journal of Thoracic and Cardiovascular Surgery·Aritoshi HattoriKenji Suzuki
Nov 26, 2019·The Annals of Thoracic Surgery·Xiaozheng KangKe-Neng Chen

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