Lobular breast cancer: molecular basis, mouse and cellular models

Breast Cancer Research : BCR
Matthias Christgen, Patrick W B Derksen

Abstract

Infiltrating lobular breast cancer (ILC) is the most common special breast cancer subtype. With mutational or epigenetic inactivation of the cell adhesion molecule E-cadherin (CDH1) being confined almost exclusively to ILC, this tumor entity stands out from all other types of breast cancers. The molecular basis of ILC is linked to loss of E-cadherin, as evidenced by human CDH1 germline mutations and conditional knockout mouse models. A better understanding of ILC beyond the level of descriptive studies depends on physiologically relevant and functional tools. This review provides a detailed overview on ILC models, including well-characterized cell lines, xenograft tumors and genetically engineered mouse models. We consider advantages and limitations of these models and evaluate their representativeness for human ILC. The still incompletely defined mechanisms by which loss of E-cadherin drives malignant transformation are discussed based on recent findings in these models. Moreover, candidate genes and signaling pathways potentially involved in ILC development and progression as well as anticancer drug and endocrine resistance are highlighted.

References

Sep 1, 1974·Journal of the National Cancer Institute·R CailleauW J Reeves
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·D RiethmacherC Birchmeier
Nov 27, 1996·International Journal of Cancer. Journal International Du Cancer·P D RyeO Fodstad
Apr 16, 1998·Nature·P GuilfordA E Reeve
Dec 2, 1998·International Journal of Cancer. Journal International Du Cancer·A F GazdarJ W Shay
Apr 17, 1999·Molecular and Cellular Biology·J M Daniel, A B Reynolds
Apr 29, 1999·Journal of Mammary Gland Biology and Neoplasia·R D Cardiff, S R Wellings
Apr 6, 2001·International Journal of Cancer. Journal International Du Cancer·S DroufakouI R Hart
Jun 7, 2002·Mechanisms of Development·Oréda BoussadiaRolf Kemler
Jan 6, 2004·Proceedings of the National Academy of Sciences of the United States of America·Christopher L TinkleElaine Fuchs
Jun 3, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M Tubiana-HulinJ Rouëssé
Jun 17, 2006·Molecular Cancer Research : MCR·Danielle MeijerLambert C J Dorssers
Jul 19, 2006·Veterinary Pathology·C E WoodJ M Cline
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jorge Sergio Reis-FilhoAlan Ashworth
Jun 26, 2007·Journal of Mammary Gland Biology and Neoplasia·Jos Jonkers, Patrick W B Derksen
Jul 4, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elisabetta MarangoniMarie-France Poupon
Nov 24, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emad A RakhaIan O Ellis
Jan 22, 2008·Biochimica Et Biophysica Acta·Carien M Niessen, Cara J Gottardi
Nov 1, 2008·Cancer Research·Rebecca B RigginsRobert Clarke
Feb 19, 2009·Cancer Research·Bostjan HumarParry Guilford
Jul 14, 2009·Breast Cancer Research and Treatment·Antoinette HollestelleMieke Schutte
Sep 19, 2009·Breast Cancer Research and Treatment·Antoinette HollestelleMieke Schutte
Jan 27, 2011·Veterinary Pathology·M GoldschmidtV Zappulli
Feb 18, 2011·EMBO Molecular Medicine·Fabrice SircoulombChristophe Ginestier
Jul 13, 2011·The Journal of Clinical Investigation·Ron C J SchackmannPatrick W B Derksen
Sep 3, 2011·Breast Cancer Research : BCR·Deborah L Holliday, Valerie Speirs
Oct 18, 2011·Breast Cancer Research and Treatment·P CottuD Decaudin
Feb 23, 2012·Cellular Oncology (Dordrecht)·Cigdem ErcanPatrick W B Derksen
Sep 5, 2012·Laboratory Investigation; a Journal of Technical Methods and Pathology·Matthias ChristgenUlrich Lehmann

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Citations

Jan 16, 2016·Histopathology·Rita Canas-Marques, Stuart J Schnitt
Apr 8, 2015·Breast Cancer Research : BCR·Amy E McCart ReedPeter T Simpson
May 29, 2016·Pathology, Research and Practice·Matthias ChristgenHans Kreipe
Sep 22, 2016·Breast Cancer Research : BCR·Matthew J SikoraSteffi Oesterreich
Sep 24, 2015·Cellular Oncology (Dordrecht)·Cathy B MoelansPatrick W B Derksen
Oct 17, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mieke RaapMatthias Christgen
Jul 15, 2016·Journal of Mammary Gland Biology and Neoplasia·Milou TenhagenPatrick W B Derksen
Mar 15, 2018·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Yayoi AdachiHiroji Iwata
Jul 22, 2018·Future Oncology·Diogo EstêvãoRui Medeiros
Feb 25, 2019·Breast Cancer Research and Treatment·Emily A BossartSteffi Oesterreich
May 17, 2017·Cold Spring Harbor Perspectives in Biology·Heather C Bruner, Patrick W B Derksen
Apr 4, 2018·Cancer Discovery·Ilirjana BajramiChristopher J Lord
Feb 2, 2021·Frontiers in Oncology·Natalie WilsonOlga Oikonomidou
Feb 23, 2021·EMBO Molecular Medicine·George SflomosCathrin Brisken

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Methods Mentioned

BETA
xenograft
xenografts

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